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1

Production of proteins in the cell-free expression systems

100%
Szaflarski W., Sujka P., Nowicki M., Zabel M.
Biotechnologia
|
2009
|
issue 1
86-97
EN
Efficient protein synthesis has become a critical issue in recent biotechnology and functional protemic studies. Traditional expression of protein performed in host cells such as Escherichia coli or Saccharomyces cerevisiae is generally lengthy and costly. Cell-free protein synthesis is an attractive alternative offering simplicity and fast rate of the reaction as well as the generation of functional proteins that are difficult to obtain using in vivo systems. Furthermore, the open nature of these systems makes it amenable to manipulation allowing the investigations into the mechanism of protein synthesis itself and into the inhibition of that process by interfering molecules such as antibiotics. Here we review all the main classes of cell-free protein expression system and we emphasize their potency and recent applications in biotechnology.
2

Structure and function of intersubunit bridges in procaryotic ribosome

100%
Kietrys A. M., Szopa A., Bakowska-Zywicka K.
Biotechnologia
|
2009
|
issue 1
48-58
EN
The main function of ribosome is decoding of the genetic message and formation of peptide bonds. Protein synthesis is a dynamic process during which tRNA and mRNA are translocated through the ribosome. Ribosomal subunits, small and large, are joined together by a series of bridges, which make possible forming of an active ribosome. It this paper we present the functional importance of ribosomal bridges.
3

Antisense makes sense in protein biosynthesis regulation

100%
Twardowski T.
Biotechnologia
|
1993
|
issue 3
134-137
EN
occurs in nature with frequency error better than 10-4. Regulation of is caused by several factors. Recently the effect of on in vivo as well as in vitro has been presented. The specific recognition of substrate by ribozyme is also determined by sense-antisense hybridization reaction of ribozymes flanking sequences.
4

Antisense strategy in translational regulation of protein biosynthesis. Perspectives on plant agrobiotechology

100%
Nawrot M., Sobkiewicz A., Twardowski T.
Biotechnologia
|
1994
|
issue 4
92-101
EN
Model research with antisense strategy on plant system at translational level (26S rRNA and 5S rRNA) are presented.The perspective application of this technology for Polish agriculture is discussed.
5

The structure of the ribosome-short history

100%
Bakowska-Zywicka K., Tyczewska A.
Biotechnologia
|
2009
|
issue 1
99-103
EN
Ribosomes, which are ?the heart of the protein biosynthesis' have been the focus of structural studies for more than 50 years. The reconstitution of some of the morphological features of the ribosome was performed many years ago. In the past few years, high-resolution structures provided molecular details of different intermediates in ribosome-mediated translation. Together, these studies have revolutionized our understanding of the mechanism of protein biosynthesis. This success depended strictly on the advances in biochemical, biophysical and genetic studies and macromolecular crystallography that have been made during last decades.
6

Molecular basics of protein biosynthesis ? function of 23S rRNA

100%
Bakowska-Zywicka K., Kietrys A.
Biotechnologia
|
2007
|
issue 1
186-196
EN
The main function of ribosome is to serve as a site of mRNA translation into a sequence of amino acids in a process called protein biosynthesis. Most important for understanding the translational mechanism is how a ribosome interacts with the factors playing role in this complicated cellular process. The key elements of these interactions are the functional domains of rRNAs. In this paper, we present the functional importance of 23S rRNA in polypeptide biosynthesis.
7

Function of selected fragments of 16S rRNA of small ribosomal subunit in protein biosynthesis

100%
Bakowska K.
Biotechnologia
|
2005
|
issue 2
206-214
EN
The mechanism of protein biosynthesis and selected fragments of rRNAs are universally conserved. Understanding structural basis for the functional capabilities of rRNAs is essential to regulation of protein synthesis. In this paper I describe function of the most important fragments of 16S rRNA of small ribosomal subunit.
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