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1
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Hydrogen-Induced Changes in Palladium Surface Structure: Field Ion Microscopy Study

100%
Tomaszewska A., Stępień Z.
Acta Physica Polonica A
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2008
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vol. 114
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issue S
S-135-S-140
EN
In this work the field ion microscopy technique was used in order to examine hydrogen-induced changes in palladium surface structure in the context of surface palladium hydrides formation. The goal of the study is to determine the crystallographic planes on which the particles of interest are formed with greatest intensity. Employing a method which consists in finding the differences in the brightness of field ion microscopy images we found that the structures of palladium surface hydrides, the size of which varies from 1 to 30 nm, develop mainly on {110} planes of palladium.
2
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An Influence of Ageing on the Structure, Corrosion Resistance and Hardness of High Aluminum ZnAl40Cu3 Alloy

100%
Michalik R., Tomaszewska A.
Archives of Metallurgy and Materials
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2016
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issue 1
3

Chromosome abnormalities without phenotypic consequences

81%
Kowalczyk M., Srebniak M., Tomaszewska A.
Journal of Applied Genetics
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2007
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vol. 48
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issue 2
157-166
EN
Some changes in chromosome morphology, detected during cytogenetic analysis, are not associated with clinical defects. Therefore a proper discrimination of harmless variants from true abnormalities, especially during prenatal diagnosis, is crucial to allow precise counseling. In this review we described chromosome variants and examples of chromosome anomalies that are considered to be unrelated to phenotypic consequences. The correlation between the presence of marker chromosomes and a risk of clinical signs is also discussed. Structural rearrangements of heterochromatic material, satellite polymorphism, or fragile sites, are well-known examples of common chromosome variation. However, the absence of clinical effects has also been reported in some cases of chromosome abnormalities concerning euchromatin. Such euchromatic anomalies were divided into 2 categories: unbalanced chromosome abnormalities (UBCAs), such as deletions or duplications, and euchromatic variants (EVs). Recently so-called molecular karyotyping, especially whole-genome screening by the use of high-resolution array-CGH technique, contributed to revealing a high number of previously unknown small genomic variations, which seem to be asymptomatic, as they are present in phenotypically normal individuals.
4
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The Influence of Deformation Method on the Microstructure and Properties of Magnesium Alloy WE43

81%
Bednarczyk I., Kuc D., Tkocz M., Tomaszewska A.
Archives of Metallurgy and Materials
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2018
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vol. 63
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issue 4
5
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The Influence of Extrusion Process on the Microstructure and Mechanical Properties of Magnesium Alloys

81%
Tomaszewska A., Bednarczyk I., Kuc D., Mrugała A.
Archives of Metallurgy and Materials
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2017
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vol. 62
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issue 2
6
Content available remote

Study of the Structure and Thermal Properties of Intermetallics from Fe-Al System

81%
Śmiglewicz A., Rodak K., Tomaszewska A.
Acta Physica Polonica A
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2016
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vol. 130
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issue 4
1004-1006
EN
Selected alloys from the Fe-Al system are included into a group of materials on a matrix of intermetallic phases, and characteristic properties result from it and they constitute a resultant between properties of superalloys and ceramic materials. These materials are characterized, inter alia, by capacity for operating at elevated temperatures, as well as good strength related properties and resistance to oxidation and corrosion at an increased temperature. In addition, a low cost of alloy components and low density caused by aluminium content are their advantages. The basic reasons limiting application of alloys from Fe-Al system as construction materials are current: their low plasticity at room temperature, propensity for brittle cracking, low resistance at elevated temperature, and insufficient creep resistance. This unfavorable characteristics may be improved by adding to alloys such elements as molybdenum, zirconium, carbon, and boron, reducing the size of grains, increasing their purity, stabilizing the solid solution, and causing changes in phase transition temperatures. These alloys may be successfully manufactured by classic melting accompanied with refinement remelting, and ingot casting. In spite of additions and microadditions, grain refining of the initial structure of ingots manufactured in that way is rarely achieved, mainly because of low castability and high casting contraction. In this work we presented the results of structure analysis and investigations of the dilatometric study alloys on the base Fe-Al system. The alloys were obtained by classic casting technique. The studies were carried out on samples after casting and annealing. The phase transformation and thermal expansion investigations of the alloys from Fe-Al system with concentration of Fe-58Al were presented. The linear thermal expansion α was calculated by standard method. The α coefficient was noticed as a temperature function.
7
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Influence of Plastic Deformation Process on the Structure and Properties of Alloy WE43

80%
Tomaszewska A., Bednarczyk I., Mrugała A.
Archives of Metallurgy and Materials
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2016
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issue 1
8
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Primary Microstructure Characterization of As-Casted Co-20Ni-7Al-7W Superalloy

72%
Tomaszewska A., Moskal G., Mikuszewski T., Junak G., Płachta A., Tomaszewska A., Moskal G., Mikuszewski T., Junak G., Płachta A.
Archives of Foundry Engineering
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2019
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vol. 19
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issue 3
9
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The Effect of Extrusion in the Complex Strain State on the Microstructure and Mechanical Properties of MgAlZn Magnesium Alloys

72%
Bednarczyk I., Kuc D., Tomaszewska A., Tkocz M., Bednarczyk I., Kuc D., Tomaszewska A., Tkocz M.
Archives of Metallurgy and Materials
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2020
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vol. 65
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issue 3
10

Subfertile couple with t(4;22)(q23;q11.2)

71%
Srebniak M., Popowska L., Wawrzkiewicz-Witkowska A., Tomaszewska A., Kazmierczak W.
Journal of Applied Genetics
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2005
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vol. 46
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issue 3
333-336
EN
A couple was referred for cytogenetic examination due to idiopathic miscarriages. The proband proved to be a carrier of chromosomal translocation and her partner's karyotype was found to be normal. The karyotype of the proband is 46,XX,t(4;22)(q23;q11.2) and can be regarded as a reason of fertility problems in the investigated couple. The risk of further miscarriages is high, but the risk of a progeny with abnormal karyotype is rather low, as the progeny would probably have lethal imbalances.
11

Comparison of two methods used for monitoring low-copy cytomegalovirus infection in a patient with chronic myeloid leukemia after unrelated umbilical cord blood transplantation

71%
Dzieciatkowski T., Przybylski M., Tomaszewska A., Rokicka M., Luczak M.
Archivum Immunologiae et Therapiae Experimentalis
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2007
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vol. 55
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issue 3
199-203
EN
Introduction: Detection of human cytomegalovirus (CMV, HHV-5) DNA in clinical specimens is considered a cornerstone in the diagnosis of HHV-5 disease. The present study compared two quantitative methods used for diagnosing cytomegalovirus infection in a 21-year-old woman with chronic myeloid leukemia after an unrelated umbilical cord blood transplantation. Materials and Methods: Blood samples were tested for the presence of HHV-5 DNA using the LightCycler PCR, the quantitative Eclipse? CMV DNA Detection Kit, and a qualitative in-house PCR assay using primers that amplify part of the HHV-5 MIE gene. Results: Results from samples containing a low cytomegalovirus load were more accurate with the LightCycler test than those obtained with the Eclipse? test, which underestimated the viral load of samples containing low DNA copy numbers. Conclusions: These findings underline the value of novel PCR methods used in current therapeutic procedures and in monitoring antiviral therapy with nucleoside analogs. The high level of sensitivity, specificity, accuracy, and rapidity provided by the LightCycler instrument are favorable for the use of this system in the detection of HHV-5 DNA in clinical specimens.
12

Prevalence of human herpesvirus 6 antibodies and DNA in allogeneic stem cell transplant patients: two-year single centre experience

71%
Dzieciatkowski T., Przybylski M., Torosian T., Tomaszewska A., Luczak M.
Archivum Immunologiae et Therapiae Experimentalis
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2008
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vol. 56
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issue 3
201-206
EN
Human herpesvirus 6 (HHV-6) has been recognized as a potentially significant pathogen in hemopoietic stem cell transplant (HSCT) recipients. Different clinical manifestations have been described, including fever, skin rash, bone marrow suppression, and encephalitis. Materials and Methods: A retrospective review of a group of 26 adult recipients of allogeneic HSCTs was conducted. Serum samples taken before transplant were examined for the presence of specific anti-HHV-6 IgM and IgG antibodies. After transplantation, quantitative real-time PCR was used to determine viral load in plasma samples from days 0?180 post-transplant. Results: HHV-6 DNA was detected in plasma samples in 8 (30%) of the 26 recipients between days 18 and 40 after transplantation. All of them developed fever of unknown origin and over 50% had graft-versus-host disease features. Three individuals from this group died during detectable HHV-6 viremia. Another two recipients showed a single positive PCR result at a later time. Infection with HHV-6 was thus confirmed in 10 (38.5%) of the 26 graft recipients. Conclusions: There is a high frequency of detectable HHV-6 viral load in stem cell transplant recipients in Poland. Further investigation to monitor HHV-6 reactivation in graft recipients will be important to improve outcome for these patients.
13

Simultaneous transplantation of two allogeneic units of cord blood in an adult patient with acute myeloblastic leukemia. A case report

42%
Wiktor-Jedrzejczak W., Rokicka M., Urbanowska E., Torosian T., Graczyk-Pol E., Tomaszewska A., Krol M., Paluszewska M., Gronkowska A., Ziarkiewicz-Wroblewska B., Jolkowska J., Witt M.
Archivum Immunologiae et Therapiae Experimentalis
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2005
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vol. 53
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issue 4
364-368
EN
The major obstacle to the therapeutic use of hematopoietic transplantation is the unavailability of matched, unrelated marrow donors for the large number of potential patients, although all of them have the chance to find sufficiently matched, unrelated cord blood units. However, the use of cord blood as a source of cells for transplantation is limited by its cell number, usually below 1 billion, which allows for routine transplantation only in children weighting less than 30 kg, while most potential recipients possess a higher body mass. This led to the idea of the simultaneous use of several units of cord blood which, combined, would fulfill the requirements for the necessary cell number for an adult recipient. We attempted to simultaneously transplant an adult patient with refractory acute myeloblastic leukemia utilizing two different cord blood units, one fully matched and one mismatched at one locus. The patient became reconstituted with only one unit, the mismatched, as determined using microsatellite markers, and had no signs of relapse of leukemia. Unfortunately, he died of persistent fungal (brain aspergilloma) infection on day +103. The successful engraftment may suggest that a method based on the principle of using more than one cord blood unit for transplantation is feasible in large adult patients and may reach routine application.
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