Is tumor expression of the major histocompatibility complex antigen required for T cell immune surveillance?

• Authors: Y. Liu , P. Zheng
• Languages of publication: EN

Abstracts

EN

Tumor expression of major histocompatibility complex antigen (MHC) class I and class II is not essential for the induction of memory T cells. However, induction of MHC class I-restricted effector cytotoxic T cells (CTL) appears dependent on MHC class I expression on tumors. Moreover, the effector function of tumor-specific CTL requires direct recognition of the tumor. In contrast, both the inductive and the effector phases of MHC class II-restricted T cells are independent of MHC class II expression on tumors.

Keywords

EN

IMMUNE SURVEILLANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; TUMOR IMMUNITY

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2001
• Volume: 49
• Issue: 2 suppl.
• Pages: 61-64

Contributors

author

Y. Liu

author

P. Zheng

• Document Type: REVIEW
• Publication order reference: Y. Liu, Department of Pathology, Ohio State University Medical Center, Columbus, OH 43210, USA