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Production of an MHC class II B molecular probe in the turkey, Meleagris gallopavo

100%

Jones_ D. M. D., Locklear C. C., Buchholz R., Hecht S. J., Findley A. M.

Journal of Applied Genetics

2003

vol. 44

issue 3

369-373

Genetic selection for disease resistance may be facilitated by molecular markers of the major histocompatibility complex (MHC) of poultry. We describe the first sequence variation documented at the MHC Class II B region of turkeys, and provide specific probe optimization conditions for studying RFLP polymorphisms in this species.

Is tumor expression of the major histocompatibility complex antigen required for T cell immune surveillance?

80%

Liu Y., Zheng P.

Tumor expression of major histocompatibility complex antigen (MHC) class I and class II is not essential for the induction of memory T cells. However, induction of MHC class I-restricted effector cytotoxic T cells (CTL) appears dependent on MHC class I expression on tumors. Moreover, the effector function of tumor-specific CTL requires direct recognition of the tumor. In contrast, both the inductive and the effector phases of MHC class II-restricted T cells are independent of MHC class II expression on tumors.

Genetic background of cutaneous forms of lupus erythematosus: update on current evidence

70%

Osmola A., Namysl J., Jagodzinski P. P., Prokop J.

Journal of Applied Genetics

2004

vol. 45

issue 1

77-86

This article reviews and updates current information on the possible genetic basis for cutaneous lupus erythematosus. The aetiology of this condition remains unknown and is believed to be multifactorial, involving genetic, environmental and retroviral factors. A genetic predisposition is probably the greatest risk factor for this condition. Individual susceptibility to lupus erythematosus may be determined by a combination of specific polymorphisms of genes encoding multiple cytokines, adhesion molecules, and cellular proteins. This condition may lead to an abnormal expression of immunoregulatory molecules and finally results in the development or exacerbation of the disease. Recently also the role of endogenous retroviral sequences in the pathogenesis of autoimmunity has been discussed.

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2 Journal of Applied Genetics

1 Archivum Immunologiae et Therapiae Experimentalis

1 2004

1 2003

1 2001

1 Buchholz R.

1 Findley A. M.

1 Hecht S. J.

1 Jagodzinski P. P.

1 Jones_ D. M. D.

1 Liu Y.

1 Locklear C. C.

1 Namysl J.

1 Osmola A.

1 Prokop J.

1 Zheng P.

Search results

Production of an MHC class II B molecular probe in the turkey, Meleagris gallopavo

Is tumor expression of the major histocompatibility complex antigen required for T cell immune surveillance?

Genetic background of cutaneous forms of lupus erythematosus: update on current evidence