Characterization of a novel transcript variant of human STAU1 gene

• Authors: Nie Fa-hui , Yao Hai-feng , Qi Rui-feng , Li Xin , Wu Cai-bin
• Languages of publication: EN

Abstracts

EN

Human STAU1 is one member of the family of double-stranded RNA (dsRNA)-binding proteins. It is thought to function in transporting mRNA, controlling translation and eliciting mRNA decay in neurons, and to function in infection of influenza virus and human immunodeficiency virus type 1 (HIV-1). Four transcripts coding two isoforms have been identified before. In this study, we have isolated a novel transcript of STAU1, coding a novel isoform that has six amino acids more (SFPLKQ) than isoform a. In order to examine the tissue distribution of this novel isoform, we have performed RT-PCR experiments and the analysis showed that it was highly expressed in heart, liver, kidney and pancreas.

Keywords

EN

expression pattern; STAU1

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2008
• Volume: 55
• Issue: 3
• Pages: 473-478

Dates

published

2008

received

2008-03-09

revised

2008-08-11

accepted

2008-08-15

(unknown)

2008-09-20

Contributors

author

Nie Fa-hui

• State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai, PR China

author

Yao Hai-feng

• State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai, PR China

author

Qi Rui-feng

• Institute of Protein Research, Tongji University, Shanghai, PR China

author

Li Xin

• Institute of Biomedical science, Fudan University, Shanghai, PR China

author

Wu Cai-bin

• Institute of Environment Engineering Research, East China Jiao Tong University, Nanchang, PR China

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