Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin

• Authors: Marta Michalska , Wojciech Pająk , Justyna Kołodziejska , Andrzej Łazarenkow , Jolanta Nawrot-Modranka
• Languages of publication: EN

Abstracts

EN

The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.

Keywords

EN

fibrin; chromone; coumarin; polymerization; viscosity; phosphorohydrazone

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2008
• Volume: 55
• Issue: 3
• Pages: 613-617

Dates

published

2008

received

2008-08-18

revised

2008-09-12

accepted

2008-09-16

(unknown)

2008-09-18

Contributors

author

Marta Michalska

• Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland

author

Wojciech Pająk

• Department of Analytical Chemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland

author

Justyna Kołodziejska

• Chair of Applied Pharmacy, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland

author

Andrzej Łazarenkow

• Department of Bioinorganic Chemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland

author

Jolanta Nawrot-Modranka

• Department of Bioinorganic Chemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland

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