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2017 | 22 | 4 | 67-71
Article title

Wpływ diety na rozwój chorób alergicznych

Title variants
Role of diet in the development of allergic diseases
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Overweight and obesit, as well as allergies, represent a growing problem in all developed countries. An interesting issue is the impact of these health problems on one another. At present, a characteristic phenotype of asthma associated with obesity is distinguished. There is plenty of evidence that weight loss results in improved bronchial asthma control. What is more, weight gain can aggravate the course of asthma. Adipose tissue is immunologically active, which may be an important factor in the development of allergies. It is known that allergic inflammation is promoted by some cytokines and interleukins. Weight gain results in an increase of levels of Il-6, leptin, TNF-alpha. Il-6 and leptin influence the decrease in T-regs activity. The relationship between asthma and obesity is evident, but does diet affect the development of other atopic diseases? In this article we attempt to answer this question based on the latest publications.
Nadwaga i otyłość, podobnie jak alergia, stanowią coraz większy problem w krajach rozwiniętych. Interesującym zagadnieniem jest wpływ tych problemów zdrowotnych na siebie nawzajem. Obecnie wyodrębnia się charakterystyczny fenotyp astmy związanej z otyłością. Istnieje szereg dowodów, że utrata masy ciała powoduje poprawę kontroli astmy oskrzelowej w tym fenotypie astmy. Co więcej przyrost masy ciała pogarsza przebieg astmy. Tkanka tłuszczowa jest immunologicznie czynna, przez co wydaje się, że może mieć istotne znaczenie w rozwoju alergii. Wiadomo, że proces zapalny o charakterze alergicznym jest promowany przez niektóre cytokiny i interleukiny. Wzrost masy ciała powoduje wzrost poziomu krążącej Il 6, leptyny, TNF-alfa. Il-6 i leptyna wpływają na spadek aktywności limfocytów T regulatorowych (T regs). Związek pomiędzy astmą oskrzelową a otyłością jest ewidentny, jednak czy dieta wywiera wpływ na rozwój innych chorób atopowych? W pracy podjęto próbę odpowiedzi na to pytanie w oparciu o najnowsze publikacje.
BMI   alergia   astma   dieta   otyłość  

Physical description
  • Katedra i Klinika Alergologii, Immunologii Klinicznej i Chorób Wewnętrznych, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, UMK
  • Katedra Higieny, Epidemiologii i Ergonomii, Zakład Ergonomii i Fizjologii Wysiłku Fizycznego, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, UMK
  • Katedra i Klinika Alergologii, Immunologii Klinicznej i Chorób Wewnętrznych, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, UMK
  • Katedra i Klinika Alergologii, Immunologii Klinicznej i Chorób Wewnętrznych, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, UMK
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