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2015 | 20 | 254-259
Article title

EFFECT OF CHITOSAN ON THE RHEOLOGICAL PROPERTIES OF HYDROGELS BASED ON SODIUM CARBOXYMETHYLCELLULOSE

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EN
Abstracts
EN
The aim of the study was to evaluate the effect of changing the concentrations of chitosan on the rheological properties of the obtained formulation. Hydrogels were prepared with 1% hydrocortisone containing 4% sodium carboxymethylcellulose with the addition of chitosan, propylene glycol-1,2 or polyethylene glycol 400 and glycerol or paraffin. The concentration of chitosan and excipients affects the rheological properties of gels and the pharmaceutical availability of hydrocortisone. Increasing the concentration of chitosan have influence on increasing the viscosity, hardness, and cohesiveness of the tested gels.
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Year
Volume
20
Pages
254-259
Physical description
Contributors
  • Faculty of Pharmacy Wrocław Medical University, ul. Borowska 211 A, 50-556 Wrocław, Poland
author
  • Faculty of Pharmacy Wrocław Medical University, ul. Borowska 211 A, 50-556 Wrocław, Poland
author
References
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  • 2. Szcześniak M, Gasztych M, Pluta J; (2013) Effect of the medium composition on the properties of gels based on sodium carboxymethylcellulose. Polim Med 4, 235-239.
  • 3. De Moura MR, Aouada FA, Mattoso LHC, Zucolotto V; (2013) Hybrid nanocomposites containing carboxymethylcellulose and silver nanoparticles. J Nanosci Nanotechnol 3, 1946–1950.
  • 4. Hashem M, Sharaf S, Abd El-Hady MM, Hebeish A; (2013) Synthesis and characterization of novel carboxymethylcellulose hydrogels and carboxymethylcellulolse-hydrogel-ZnO-nanocomposites. Carbohydr Polym 95, 421-427. DOI: 10.1016/j.carbpol.2013.03.013
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  • 7. Kubiak T; (2014) The Use of Shells Made of Poly(Ethylene Glycol) and Chitosan to Ensure the Biocompatibility of Nanoparticles in Biomedical Applications. Polim. Med 44,2,119-127.
  • 8. Modrzejewska Z; (2011) Formy chitozanowe do zastosowań w inżynierii biomedycznej. Inż Ap Chem 50,5,74-75.
  • 9. Ray SD; ( 2011) Potential aspects of chitosan as pharmaceutical excipient. Acta Pol Pharm 68, 619-622.
  • 10. Szcześniak M, Pluta J; (2013) The effect of selected excipients on properties hydrogels on the basis Carbopol 934 P. Polim Med 43, 29-34.
  • 11. Szcześniak M, Pluta J; (2011) Influence of polymers on hydrogels with hydrocortysone properties. Polim Med 41, 43-47.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-b4d8ab00-45df-430c-bced-da3828ddf57d
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