EFFECT OF CHITOSAN ON THE RHEOLOGICAL PROPERTIES OF HYDROGELS BASED ON SODIUM CARBOXYMETHYLCELLULOSE

• Authors: Maria Szcześniak , Bożena Grimling , Janusz Pluta , Jan Meler
• Languages of publication: EN

Abstracts

EN

The aim of the study was to evaluate the effect of changing the concentrations of chitosan on the rheological properties of the obtained formulation. Hydrogels were prepared with 1% hydrocortisone containing 4% sodium carboxymethylcellulose with the addition of chitosan, propylene glycol-1,2 or polyethylene glycol 400 and glycerol or paraffin. The concentration of chitosan and excipients affects the rheological properties of gels and the pharmaceutical availability of hydrocortisone. Increasing the concentration of chitosan have influence on increasing the viscosity, hardness, and cohesiveness of the tested gels.

Keywords

EN

chitosan; pharmaceutical availability; rheological parameters; sodium carboxymethylcellulose

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2015
• Volume: 20
• Pages: 254-259

Contributors

author

Maria Szcześniak

• Faculty of Pharmacy Wrocław Medical University, ul. Borowska 211 A, 50-556 Wrocław, Poland

author

Bożena Grimling

• Faculty of Pharmacy Wrocław Medical University, ul. Borowska 211 A, 50-556 Wrocław, Poland

author

Janusz Pluta

• Faculty of Pharmacy Wrocław Medical University, ul. Borowska 211 A, 50-556 Wrocław, Poland

author

Jan Meler

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• Document Type: article