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Journal
2013 | 41 | 2 | 11-14
Article title

The use of alginate impression material for the controlled release of sodium fusidate

Title variants
PL
Zastosowanie alginatowej masy wyciskowej do kontrolowanego wydzielania fusydanu sodu
Languages of publication
EN
Abstracts
EN
Introduction. Alginate impression material has the potential to act as a controlled release material, either for transmucosal drug delivery, or for use as a self-disinfecting impression material in clinical dentistry. Aim of the study. To study whether sodium fusidate could be released from alginate impression material and, if so, to determine the release kinetics. Material and methods. Sodium fusidate was incorporated into alginate impression material at the mixing stage (2% by mass). The mixed material was pressed into a sheet and, once cured, discs (6 mm diameter x 2 mm thick) were cut out, and stored in water, one disc in a 5 ml volume. Small samples (20 μl) were withdrawn at time intervals of 1, 2, 3, 4, 5, 24 h, 1, 2 and 3 weeks and analysed by HPLC. Results. Sodium fusidate was released from the impression material in a process that was shown to be diffusion based for the first 5 hours or so. The diffusion coefficient was 2.25 x 10-5 cm2 s-1, and the release corresponded to 36.0 ± 1.0% of the total loading. The system thus shows promise for clinical application.
PL
Wstęp. Alginatowe masy wyciskowe mogą być potencjalnie użyte jako materiały służące do kontrolowanego uwalniania, np. leków wchłanianych przez błonę śluzową czy środków dezynfekcyjnych, które umożliwiałyby autodezynfekcję wycisków w warunkach klinicznych. Cel pracy. Ocena czy fusydan sodu może być wydzielany z alginatowych mas wyciskowych oraz ocena kinetyki wydzielania. Materiał i metody. Fusydan sodu wprowadzono podczas mieszania do alginatowej masy wyciskowej w proporcji 2% masowych. Z zamieszanego materiału uformowano cienką warstwę, po związaniu wycięto próbki w kształcie krążka (6 mm średnicy x 2 mm grubości), każdą próbkę przechowywano oddzielnie w 5 ml wody. Po upływie kolejno 1, 2, 3, 4, 5, i 24 godzin a następnie 1, 2 i 3 tygodni pobierano niewielkie ilości roztworu, który poddawano analizie w HPLC. Wyniki. Fusydan sodu w ciągu pierwszych 5 godzin był wydzielany z masy wyciskowej w procesie dyfuzji. Współczynnik dyfuzji wynosił 2.25 x 10-5 cm2 s-1, wydzielona ilość odpowiadała 36.0 ± 1.0%. W związku z tym ten system wydaje się być obiecujący w warunkach klinicznych.
Discipline
Publisher

Journal
Year
Volume
41
Issue
2
Pages
11-14
Physical description
Dates
published
2013
Contributors
References
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Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-1732-0801-1
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