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2012 | 17 | 21 - 28
Article title

MODIFICATION OF RELEASE RATE OF SALICYLIC ACID FROM CHITOSAN MEMBRANE

Content
Title variants
Languages of publication
EN
Abstracts
EN
Due to continued interest in biodegradable polymers, chitosan is one of the most commonly used polymers in the field of control release of active substances. Currently as carriers of drugs, among tablets, or micro spheres transdermal systems, called films, are used. The presented results apply to study a drug release in buffer of pH = 7.2 from chitosan film. To study the kinetics of controlled release salicylic acid was used as a model substance. Obtained films were cross-linked in TPP solution and were also modified by applying outsider layer to slow down the release process. Received transdermal systems were tested with swelling kinetics and the release kinetics of salicylic acid. The obtained systems were tested in relation to different temperature of cross-linking solution of chitosan, different thickness of studied matrices, the influence of outside layer and varying initial amount of salicylic acid.
Publisher

Year
Volume
17
Pages
21 - 28
Physical description
Contributors
author
  • Faculty of Process and Environmental Engineering, Technical University of Lodz, ul. Wolczanska 213, 90-924, Lodz, Poland, muchama@wipos.p.lodz.pl
  • Faculty of Process and Environmental Engineering, Technical University of Lodz, ul. Wolczanska 213, 90-924, Lodz, Poland
References
  • Mucha M; (2010) Chitosan universal polymer from renewable resources. (polish) WNT, ISBN 978-83-204-3566-5.
  • Patel V, Patel M, Rakesh Patel R; (2005) Chitosan: A unique pharmaceutical excipient. Drug Delivery Technology, Issue Date: Vol. 5, No. 6, 1-8.
  • Mucha M, Balcerzak J, Michalak I; (2011) Biopolymeric matrices based on chitosan for medical applications. E-Polymers, 1618-7229.
  • Farmacopea Poland pub. VI; (2002), The main part published by the Registration Office of Medicine, Medical and Biocidal Products, the Polish Pharmaceutical Society – Warsaw.
  • Gierszewska-Drużyńska M, Ostrowska-Czubenko J; (2010) Influence of cross linking process conditions on molecular and supermolecular structure of chitosan hydrogel membrane, Progress on Chemistry and Application of Chitin and Its Derivatives, 16, 15-22.
  • Kofuji K, Ito T, Murata Y, Kawashima S; (2000) The controlled release of a drug from biodegradable chitosan gel beads. Chem. Pharm. Bull 48, 579-581.
  • Shu X,Z, Zhu K,J; (2002) ‘The influence of multivalent phosphate structure on the properties of ionically cross-linked Chitozan films for controlled drug release’, s. 236.
  • Costa P, Manuel J, Lobo S; (2001) Modeling and comparison of dissolution profiles. European Journal of Pharmaceutical Sciences 13 123-133.
  • Mulye N,V, Turco S,J; (1995) A simple model based on first order kinetics to explain release of highly water soluble drugs from porous dicalcium phosphate dehydrate matrice., Drug Dev. Ind. Pharm. Vol.21, 943-953.
  • Panos M, Dokumetzidis A; (2000) On heterogenity of drug dissolution and release, Pharmaceutical Science. 17, 108-112.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-0484d89b-e7d3-4fb7-b99f-c70634daae0c
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