MODIFICATION OF RELEASE RATE OF SALICYLIC ACID FROM CHITOSAN MEMBRANE

• Authors: Maria Mucha , Iwona Michalak
• Languages of publication: EN

Abstracts

EN

Due to continued interest in biodegradable polymers, chitosan is one of the most commonly used polymers in the field of control release of active substances. Currently as carriers of drugs, among tablets, or micro spheres transdermal systems, called films, are used. The presented results apply to study a drug release in buffer of pH = 7.2 from chitosan film. To study the kinetics of controlled release salicylic acid was used as a model substance. Obtained films were cross-linked in TPP solution and were also modified by applying outsider layer to slow down the release process. Received transdermal systems were tested with swelling kinetics and the release kinetics of salicylic acid. The obtained systems were tested in relation to different temperature of cross-linking solution of chitosan, different thickness of studied matrices, the influence of outside layer and varying initial amount of salicylic acid.

Keywords

EN

chitosan; crosslinking; release; salicylic acid; transdermal systems

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2012
• Volume: 17
• Pages: 21 - 28

Contributors

author

Maria Mucha

• Faculty of Process and Environmental Engineering, Technical University of Lodz, ul. Wolczanska 213, 90-924, Lodz, Poland

author

Iwona Michalak

• Faculty of Process and Environmental Engineering, Technical University of Lodz, ul. Wolczanska 213, 90-924, Lodz, Poland

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• Document Type: article