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1993 | 45 | 1 | 1-9
Article title

Agonists and antagonists of adenosine receptors and morphine withdrawal syndrome in rats

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EN
Abstracts
EN
The compounds activating adenosine system alleviated morphine withdrawal syndrome (the number of escape attempts and body shakes) in rats. Body shakes were decreased mostly by N-ethylcarboxamidoadenosine, cyclohexyladenosine, dipyridamole and 2-chloroadenosine, while R-phenylisopropyladenosine very strongly decreased the number of escape attempts. Adenosine receptor antagonists (caffeine and theophylline) increased the number of escape attempts in morphine-dependent rats. Caffeine (10 mg/kg), administered preventively, antagonized the ingibitory effects of adenosine analogs. These results suggest the existence of relation between opioid receptors and the adenosine system.
Year
Volume
45
Issue
1
Pages
1-9
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article
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YADDA identifier
bwmeta1.element.element-from-psjc-d63e9272-4e51-3a8e-9341-d4b2eb33b3cb
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