Agonists and antagonists of adenosine receptors and morphine withdrawal syndrome in rats

• Authors: Eliza Michalska , Danuta Malec
• Languages of publication: EN

Abstracts

EN

The compounds activating adenosine system alleviated morphine withdrawal syndrome (the number of escape attempts and body shakes) in rats. Body shakes were decreased mostly by N-ethylcarboxamidoadenosine, cyclohexyladenosine, dipyridamole and 2-chloroadenosine, while R-phenylisopropyladenosine very strongly decreased the number of escape attempts. Adenosine receptor antagonists (caffeine and theophylline) increased the number of escape attempts in morphine-dependent rats. Caffeine (10 mg/kg), administered preventively, antagonized the ingibitory effects of adenosine analogs. These results suggest the existence of relation between opioid receptors and the adenosine system.

Keywords

EN

ADENOSINE RECEPTOR; ADENOSINE SYSTEM; MORPHINE; OPIOID RECEPTOR; RAT

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Institute of Pharmacology, Polish Academy of Sciences
• Journal: Polish Journal of Pharmacology
• Year: 1993
• Volume: 45
• Issue: 1
• Pages: 1-9

Contributors

author

Eliza Michalska

author

Danuta Malec

• Document Type: article