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2000 | 48 | 5 | 481-486
Article title

Nuclear import of arachidonate 5-lipoxygenase

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EN
Abstracts
EN
Leukotrienes are lipid messenger molecules that are secreted by leukocytes to orchestrate a rapid and prolonged immune response. The enzyme 5-lipoxygnease catalyzes the rate-limiting first two steps in the synthesis of leukotrienes from arachidonic acid. Although it has long been known that 5-lipoxygenase moves from the cytoplasm to a membrane following activation, it has only recently been recognized that the enzyme may shuttle into and out of the nucleus before activation. The regulation of this movement of soluble 5-lipoxygenase between the cytoplasm and the nucleoplasm, as well as its impact on 5-lipoxygenase action, leukotriene synthesis and cell function, is only now being elucidated. This review details the state of our understanding of the nuclear import of 5-lipoxygenase and its potential importance in immunity.
References
Document Type
REVIEW
Publication order reference
T.G. Brock, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
YADDA identifier
bwmeta1.element.element-from-psjc-cc717781-7a20-3c20-a79a-b5a1738e00a6
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