Nuclear import of arachidonate 5-lipoxygenase

• Authors: T.G. Brock , A. M. Healy
• Languages of publication: EN

Abstracts

EN

Leukotrienes are lipid messenger molecules that are secreted by leukocytes to orchestrate a rapid and prolonged immune response. The enzyme 5-lipoxygnease catalyzes the rate-limiting first two steps in the synthesis of leukotrienes from arachidonic acid. Although it has long been known that 5-lipoxygenase moves from the cytoplasm to a membrane following activation, it has only recently been recognized that the enzyme may shuttle into and out of the nucleus before activation. The regulation of this movement of soluble 5-lipoxygenase between the cytoplasm and the nucleoplasm, as well as its impact on 5-lipoxygenase action, leukotriene synthesis and cell function, is only now being elucidated. This review details the state of our understanding of the nuclear import of 5-lipoxygenase and its potential importance in immunity.

Keywords

EN

5-LIPOXYGENASE; LEUKOTRIENE; NUCLEAR IMPORT

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2000
• Volume: 48
• Issue: 5
• Pages: 481-486

Contributors

author

T.G. Brock

author

A. M. Healy

• Document Type: REVIEW
• Publication order reference: T.G. Brock, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA