Subfertile couple with t(4;22)(q23;q11.2)
Languages of publication
A couple was referred for cytogenetic examination due to idiopathic miscarriages. The proband proved to be a carrier of chromosomal translocation and her partner's karyotype was found to be normal. The karyotype of the proband is 46,XX,t(4;22)(q23;q11.2) and can be regarded as a reason of fertility problems in the investigated couple. The risk of further miscarriages is high, but the risk of a progeny with abnormal karyotype is rather low, as the progeny would probably have lethal imbalances.
Publication order reference
M. Srebniak, Department of Medical Genetics, The Medical University of Silesia, ul. Jedno?ci 2, 41-208 Sosnowiec, Poland