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2001 | 61 | 2 | 113-117
Article title

Sphingolipid derivatives modulate intracellular Ca2+ in rat synaptosomes

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EN
Sphingosylphosphorylcholine (SPC) induces a rapid increase of intracellular Ca2+ concentration in isolated synaptosomes. This effect is dose-dependent and is also dependent on extracellular Ca2+. Sphingosine (SPH) has a smaller effect and treatment with psychosine (PSY) is ineffective, which suggests that phosphorylation of the 1-carbon of SPH is required for the SPC to act as a Ca2+ release agonist in synaptosomes. Experiments performed in the presence of heparin or ryanodine indicate that SPC-elicited Ca2+ release is not mediated by IP3 or ryanodine receptors. Finally, our results show that the effect of SPC on Ca2+ concentration is nimodipine-sensitive, suggesting that SPC possibly activates a specific sphingolipid-gated Ca2+ channel in synaptosomes.
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Year
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61
Issue
2
Pages
113-117
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ARTICLE
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B. G. Miguel, Department of Biochemistry and Molecular Biology I, Faculty of Chemistry, Complutense University, E-28040 Madrid, Spain
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bwmeta1.element.element-from-psjc-a9b04630-a1c0-36ff-a3d9-6e9225c0f7c1
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