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1993 | 45 | 2 | 151-156
Article title

Discriminative stimulus properties of /+/-oxaprotiline in rat

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EN
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EN
Using a drug discrimination procedure on a fixed ratio (FR) 10 schedule of reinforcement, rats were trained to distinguish between the stimulus properties of the selective inhibitor of noradrenaline uptake (+)-oxaprotiline ((+)-OXA) and saline. Fifty per cent of the rats that learned to reliably discriminate (+)-OXA from saline, reached high discrimination accuracy. In substitution testing, maprotiline (MAP) and desipramine (DMI) produced dose-related responding on the (+)-OXA lever. (-)-OXA failed to show substitution. The results of our findings demonstrate that (+)-OXA may be used as a discriminative cue in rats. The NA uptake inhibition seems to be involved in the effect of this drug.
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Year
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45
Issue
2
Pages
151-156
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article
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YADDA identifier
bwmeta1.element.element-from-psjc-9ab891b8-25fa-3362-bdbc-053f9935c5da
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