Discriminative stimulus properties of /+/-oxaprotiline in rat

• Authors: Malgorzata Filip , Ewa Chojnacka-Wojcik , Edmund Przegalinski
• Languages of publication: EN

Abstracts

EN

Using a drug discrimination procedure on a fixed ratio (FR) 10 schedule of reinforcement, rats were trained to distinguish between the stimulus properties of the selective inhibitor of noradrenaline uptake (+)-oxaprotiline ((+)-OXA) and saline. Fifty per cent of the rats that learned to reliably discriminate (+)-OXA from saline, reached high discrimination accuracy. In substitution testing, maprotiline (MAP) and desipramine (DMI) produced dose-related responding on the (+)-OXA lever. (-)-OXA failed to show substitution. The results of our findings demonstrate that (+)-OXA may be used as a discriminative cue in rats. The NA uptake inhibition seems to be involved in the effect of this drug.

Keywords

EN

ANTIDEPRESSANT DRUG; DRUG DISCRIMINATION

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Institute of Pharmacology, Polish Academy of Sciences
• Journal: Polish Journal of Pharmacology
• Year: 1993
• Volume: 45
• Issue: 2
• Pages: 151-156

Contributors

author

Malgorzata Filip

author

Ewa Chojnacka-Wojcik

author

Edmund Przegalinski

• Document Type: article