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2003 | 51 | 3 | 169-177
Article title

CSF-1 as a regulator of macrophage activation and immune responses

Authors
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Languages of publication
EN
Abstracts
EN
Macrophage activation is a key determinant of susceptibility and pathology in a variety of inflammatory diseases. The extent of macrophage activation is tightly regulated by a number of pro-inflammatory cytokines (e.g. IFN-gamma, IL-2, GM-CSF, IL-3) and anti-inflammatory cytokines (e.g. IL-4, IL-10, TGF-beta). Macrophage colony stimulating factor (CSF-1/M-CSF) is a key differentiation, growth and survival factor for monocytes/macrophages and osteoclasts. The role of this factor in regulating macrophage activation is often overlooked. This review will summarise our current understanding of the effects of CSF-1 on the activation state of mature macrophages and its role in regulating immune responses.
Publisher

Year
Volume
51
Issue
3
Pages
169-177
Physical description
Contributors
author
author
References
Document Type
REVIEW
Publication order reference
M.J. Sweet, CRC for Chronic Inflammatory Diseases, Institute for Molecular Bioscience and Departments of Microbiology/Parasitology and Biochemistry, University of Queensland, Qld, 4072, Australia
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-7ad39bf4-615d-3c14-9b33-eddcdf2b9143
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