CSF-1 as a regulator of macrophage activation and immune responses

• Authors: M.J. Sweet , D.A. Hume
• Languages of publication: EN

Abstracts

EN

Macrophage activation is a key determinant of susceptibility and pathology in a variety of inflammatory diseases. The extent of macrophage activation is tightly regulated by a number of pro-inflammatory cytokines (e.g. IFN-gamma, IL-2, GM-CSF, IL-3) and anti-inflammatory cytokines (e.g. IL-4, IL-10, TGF-beta). Macrophage colony stimulating factor (CSF-1/M-CSF) is a key differentiation, growth and survival factor for monocytes/macrophages and osteoclasts. The role of this factor in regulating macrophage activation is often overlooked. This review will summarise our current understanding of the effects of CSF-1 on the activation state of mature macrophages and its role in regulating immune responses.

Keywords

EN

IMMUNE RESPONSE; INFLAMMATION; LIPOPOLYSACCHARIDE; MACROPHAGE

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2003
• Volume: 51
• Issue: 3
• Pages: 169-177

Contributors

author

M.J. Sweet

author

D.A. Hume

• Document Type: REVIEW
• Publication order reference: M.J. Sweet, CRC for Chronic Inflammatory Diseases, Institute for Molecular Bioscience and Departments of Microbiology/Parasitology and Biochemistry, University of Queensland, Qld, 4072, Australia