PL EN


Preferences help
enabled [disable] Abstract
Number of results
2000 | 60 | 2 | 203-207
Article title

Hyposensitivity to amphetamine following exposure to chlorphenvinphos - protection by amphetamine preexposure

Selected contents from this journal
Title variants
Languages of publication
EN
Abstracts
EN
We investigated the effect of an acute exposure to chlorphenvinphos (CVP), an organophosphate anticholinesterase, on amphetamine-induced open-field locomotion in rats. CVP was administered in a single i.p. dose of 1.0 mg/kg (1/10 of the LD50). All animals were challenged with 1.0 mg/kg amphetamine (AMPH) three weeks after the CVP exposure, i.e. after a time sufficient for acetylcholinesterase recovery. Some rats were also given AMPH three weeks before the CVP exposure. In rats challenged with AMPH only once after the CVP exposure, AMPH- induced open-field locomotion was significantly reduced. Such an effect was not observed in rats given AMPH three weeks before the CVP exposure. The results suggest that a single CVP exposure may result in persistent dopaminergic hyposensitivity, and that an amphetamine pretreatment may protect the rat against this effect.
Publisher

Year
Volume
60
Issue
2
Pages
203-207
Physical description
Contributors
author
author
author
References
Document Type
communication
Publication order reference
S. Gralewicz, Department of Toxicology and Carcinogenesis, The Nofer Institute of Occupational Medicine, 8 Teresy St., 90-950 Lodz, Poland, Email:gralslaw@imp.lodz.pl
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-71311b36-2808-354c-9a00-f56dd821a539
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.