Hyposensitivity to amphetamine following exposure to chlorphenvinphos - protection by amphetamine preexposure

• Authors: S. Gralewicz , P. Lutz , W. Szymczak
• Languages of publication: EN

Abstracts

EN

We investigated the effect of an acute exposure to chlorphenvinphos (CVP), an organophosphate anticholinesterase, on amphetamine-induced open-field locomotion in rats. CVP was administered in a single i.p. dose of 1.0 mg/kg (1/10 of the LD50). All animals were challenged with 1.0 mg/kg amphetamine (AMPH) three weeks after the CVP exposure, i.e. after a time sufficient for acetylcholinesterase recovery. Some rats were also given AMPH three weeks before the CVP exposure. In rats challenged with AMPH only once after the CVP exposure, AMPH- induced open-field locomotion was significantly reduced. Such an effect was not observed in rats given AMPH three weeks before the CVP exposure. The results suggest that a single CVP exposure may result in persistent dopaminergic hyposensitivity, and that an amphetamine pretreatment may protect the rat against this effect.

Keywords

EN

AMPHETAMINE; ORGANOPHOSPHATE PESTICIDE; RAT

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2000
• Volume: 60
• Issue: 2
• Pages: 203-207

Contributors

author

S. Gralewicz

author

P. Lutz

author

W. Szymczak

• Document Type: communication
• Publication order reference: S. Gralewicz, Department of Toxicology and Carcinogenesis, The Nofer Institute of Occupational Medicine, 8 Teresy St., 90-950 Lodz, Poland, Email:[e-mail]