PL EN


Preferences help
enabled [disable] Abstract
Number of results
2002 | 56 | 6 | 779-788
Article title

Molecular biology of polyglutamine diseases

Title variants
Languages of publication
PL
Abstracts
EN
Polyglutamine diseases include at least 9 neurodegenerative disorders: Huntigton?s disease (HD), dentatorubral pallidoluysian atrophy (DRPLA), spinobulbar muscular atrophy (SBMA), and spinocerebellar ataxia (SCA) type: 1-3, 6-7 and 17, each caused by a CAG-trinucleotide repeat expansion in a different gene. The poly-CAG sequence is translated into a polyglutamine stretch in the respective proteins. This review discusses mutual molecular features of polyglutamine diseases. The formation of intranuclear inclusions, recruitment of physiological polyglutamine proteins as well as a potential role of molecular chaperones, capsases, and inhibition of histone acetyltransferases-depended transcription in cellular pathogenesis are considered.
Contributors
author
author
References
Document Type
ARTICLE
Publication order reference
W. Owecki, Katedra i Klinika Neurologii AM, ul. Przybyszewskiego 49, 60-335 Poznan, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-4316cdaf-1922-383f-8b12-bcc8ba2a67e2
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.