Molecular biology of polyglutamine diseases

• Authors: M. Owecki , W. Kozubski
• Languages of publication: PL

Abstracts

EN

Polyglutamine diseases include at least 9 neurodegenerative disorders: Huntigton?s disease (HD), dentatorubral pallidoluysian atrophy (DRPLA), spinobulbar muscular atrophy (SBMA), and spinocerebellar ataxia (SCA) type: 1-3, 6-7 and 17, each caused by a CAG-trinucleotide repeat expansion in a different gene. The poly-CAG sequence is translated into a polyglutamine stretch in the respective proteins. This review discusses mutual molecular features of polyglutamine diseases. The formation of intranuclear inclusions, recruitment of physiological polyglutamine proteins as well as a potential role of molecular chaperones, capsases, and inhibition of histone acetyltransferases-depended transcription in cellular pathogenesis are considered.

Keywords

EN

NEURODEGENERATION; POLYGLUTAMINE DISEASE

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Index Copernicus International
• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 2002
• Volume: 56
• Issue: 6
• Pages: 779-788

Contributors

author

M. Owecki

author

W. Kozubski

• Document Type: ARTICLE
• Publication order reference: W. Owecki, Katedra i Klinika Neurologii AM, ul. Przybyszewskiego 49, 60-335 Poznan, Poland