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2000 | 60 | 4 | 531-545
Article title

Signaling pathways mediating anti-apoptotic action of neurotrophins

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EN
Abstracts
EN
Neurotrophins promote survival and suppress apoptosis in many populations of neurons. Currently, phosphatidylinositol-3 kinase (PI-3K) is recognized as the main mediator of this protective effect. However, most of the data collected so far on the anti-apoptotic signaling of neurotrophins were obtained using trophic withdrawal paradigms. Recent data from our and other groups indicate that extracellular-signal-regulated kinase 1/2 (Erk1/2) may play a critical role in suppressing neuronal apoptosis triggered by cellular damage. Thus, it appears that either Erk1/2 or PI-3K, depending on the nature of the death-inducing stimulus, can mediate anti-apoptotic signaling of neurotrophins. In this review, we discuss the contribution of Erk1/2 and PI-3K to neuroprotection by neurotrophins. We also present data suggesting possible mechanisms by which these pathways might suppress neuronal death.
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Year
Volume
60
Issue
4
Pages
531-545
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author
author
References
Document Type
REVIEW
Publication order reference
M. Hetman, Department of Environmental Health, University of Washington, Seattle, USA, WA98195-7234, e-mail:mhetman@u.washinton.edu
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YADDA identifier
bwmeta1.element.element-from-psjc-221d39ab-d4ff-3fe1-8097-3fa017ee2a12
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