Signaling pathways mediating anti-apoptotic action of neurotrophins

• Authors: M. Hetman , Xia Z. Xia , Z. Xia
• Languages of publication: EN

Abstracts

EN

Neurotrophins promote survival and suppress apoptosis in many populations of neurons. Currently, phosphatidylinositol-3 kinase (PI-3K) is recognized as the main mediator of this protective effect. However, most of the data collected so far on the anti-apoptotic signaling of neurotrophins were obtained using trophic withdrawal paradigms. Recent data from our and other groups indicate that extracellular-signal-regulated kinase 1/2 (Erk1/2) may play a critical role in suppressing neuronal apoptosis triggered by cellular damage. Thus, it appears that either Erk1/2 or PI-3K, depending on the nature of the death-inducing stimulus, can mediate anti-apoptotic signaling of neurotrophins. In this review, we discuss the contribution of Erk1/2 and PI-3K to neuroprotection by neurotrophins. We also present data suggesting possible mechanisms by which these pathways might suppress neuronal death.

Keywords

EN

APOPTOSIS; EXTRACELLULAR-SIGNAL-REGULATED KINASE; GLYCOGEN SYNTHASE KINASE; NEURON; SIGNAL TRANSDUCTION

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2000
• Volume: 60
• Issue: 4
• Pages: 531-545

Contributors

author

M. Hetman

author

Xia Z. Xia

author

Z. Xia

• Document Type: REVIEW
• Publication order reference: M. Hetman, Department of Environmental Health, University of Washington, Seattle, USA, WA98195-7234, e-mail:[e-mail]