Asymmetry in nucleotide composition of sense and antisense strands as a parameter for discriminating openreading frames as protein coding sequences
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Coding properties of yeast chromosomes were analysed and a strong asymmetry was found in nucleotide composition of sense and antisense strands. This property generates two very simple parameters [A]/[T] and [G]/[C] of the sense strand which could be used for discrimination of open reading frames as coding sequences with very high, statistically described level of significance. The paper contains a description of the method of ellipse of concentration in the two parameter space, which can close coding sequences inside, leaving a big fraction of noncoding sequences outside the ellipse.
Publication order reference
S.Cebrat, Institute of Microbiology, Wroclaw University, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland ,