Mycobacterium-specific human CD8 T cell responses
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Tuberculosis (TB) remains a global health problem. There is an intense effort to identify correlates of protective immunity and to design new TB vaccines. CD8 T cells are thought to play a significant role in controlling Mycobacterium tuberculosis infection. Relatively little has been published about the antigens and epitopes targeted by mycobacteria-specific CD8 T cells. Here we present an update of our 1999 overview of human CD8 T cell epitopes in mycobacterial antigens and discuss related issues relevant to TB diagnosis and vaccine development.
Publication order reference
M.R. Klein, Tuberculosis Research Programme, Medical Research Council (MRC) Laboratories, Atlantic Road, Fajara, PO Box 273, Banjul, The Gambia, West Africa