Mycobacterium-specific human CD8 T cell responses

• Authors: M.R. Klein , A. Fox
• Languages of publication: EN

Abstracts

EN

Tuberculosis (TB) remains a global health problem. There is an intense effort to identify correlates of protective immunity and to design new TB vaccines. CD8 T cells are thought to play a significant role in controlling Mycobacterium tuberculosis infection. Relatively little has been published about the antigens and epitopes targeted by mycobacteria-specific CD8 T cells. Here we present an update of our 1999 overview of human CD8 T cell epitopes in mycobacterial antigens and discuss related issues relevant to TB diagnosis and vaccine development.

Keywords

EN

DIAGNOSIS; EPITOPE; MYCOBACTERIUM TUBERCULOSIS; VACCINE

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2001
• Volume: 49
• Issue: 5
• Pages: 379-390

Contributors

author

M.R. Klein

author

A. Fox

• Document Type: REVIEW
• Publication order reference: M.R. Klein, Tuberculosis Research Programme, Medical Research Council (MRC) Laboratories, Atlantic Road, Fajara, PO Box 273, Banjul, The Gambia, West Africa