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2018 | 75 | 6 | 1313-1320
Article title

DESIGN, SYNTHESIS AND ANALYSIS OF ANTICANCER ACTIVITY OF NEW SAR-BASED S16020 DERIVATIVES

Content
Title variants
Languages of publication
EN
Abstracts
EN
A novel set of S16020 derivatives was designed applying structure activity relationships (SAR). The newly synthesized compounds were subjected to in vitro cytostatic activity screening against human kidney cancer (cell line A498), human lung cancer (cell line A549) and normal human dermal fibroblasts (cell line NHDF). Two 6H-pyrido[4,3-b]carbazole derivatives exhibited stronger potency against both investigated cell lines than the reference compounds ellipticine and doxorubicin.
Keywords
EN
A549   cytostatic   olivacine   S16020   NHDF   A498  
Year
Volume
75
Issue
6
Pages
1313-1320
Physical description
Dates
published
2018-12-31
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.doi-10_32383_appdr_89921
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