DESIGN, SYNTHESIS AND ANALYSIS OF ANTICANCER ACTIVITY OF NEW SAR-BASED S16020 DERIVATIVES

• Authors: Beata Tylińska , Ryszard Jasztold-Howorko , Karina Kowalczewska , Katarzyna Szczaurska-Nowak , Tomasz Gębarowski , Joanna Wietrzyk
• Languages of publication: EN

Abstracts

EN

A novel set of S16020 derivatives was designed applying structure activity relationships (SAR). The newly synthesized compounds were subjected to in vitro cytostatic activity screening against human kidney cancer (cell line A498), human lung cancer (cell line A549) and normal human dermal fibroblasts (cell line NHDF). Two 6H-pyrido[4,3-b]carbazole derivatives exhibited stronger potency against both investigated cell lines than the reference compounds ellipticine and doxorubicin.

Keywords

EN

A549; cytostatic; olivacine; S16020; NHDF; A498

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2018
• Volume: 75
• Issue: 6
• Pages: 1313-1320

Dates

published

2018-12-31

Contributors

author

Beata Tylińska

author

Ryszard Jasztold-Howorko

author

Karina Kowalczewska

author

Katarzyna Szczaurska-Nowak

author

Tomasz Gębarowski

author

Joanna Wietrzyk

Identifiers

DOI

10.32383/appdr/89921