Kisspeptyna - peptyd o wielu obliczach

• Authors: Kamil Ziarniak , Monika Dudek , Joanna Śliwowska

Title variants

EN

Kisspeptin - a multifunctional peptide

• Languages of publication: PL EN

Abstracts

PL

Jeszcze dekadę temu metastatyna, znana ze swojej roli w zapobieganiu powstawania przerzutów nowotworowych, dziś w swojej nowej odsłonie, jako kisspeptyna, rewolucjonizuje badania z zakresu biologii rozrodu. Kisspeptyna kryjąca pod swą nazwą grupę peptydów (o długości 10-54 aminokwasów), coraz silniej zaznacza swoją rolę w procesach dojrzewania płciowego i rozmnażania oraz stanów patologicznych, takich jak otyłość oraz cukrzyca, w których dochodzi do deregulacji osi podwzgórze-przysadka mózgowa-gonady (PPG). Obie jednostki chorobowe zostały uznane przez Światową Organizację Zdrowia za choroby cywilizacyjne i są jednym z poważniejszych wyzwań stojących przed współczesną medycyną. Z uwagi na epidemię otyłości (w Stanach Zjednoczonych jest to już problemem co trzeciego mieszkańca), coraz częściej zwraca się uwagę na korelację między podwyższoną masą ciała a zaburzeniami funkcji rozrodczych. Ponadto otyłość może w konsekwencji przyczynić się do rozwoju cukrzycy typu 2. W przypadkach obu tych schorzeń udowodniono terapeutyczny wpływ kisspeptyny. Z uwagi na to, że peptyd ten jest obecny nie tylko u ludzi, ale również u wielu innych gatunków (ryby, płazy, ptaki, ssaki) istnieje możliwość wykorzystywania licznych modeli zwierzęcych w badaniach nad kisspeptyną. Stąd też można się spodziewać dalszego poszerzania spektrum badań, zwłaszcza, iż najnowsze doniesienia pokazują, że kisspeptyna nie działa sama, ale "współpracuje" z neurokininą B (NKB) oraz dynorfiną (DYN). Niniejszy artykuł prezentuje dane wskazujące na to, że peptyd ten ma duże znaczenie w terapii zaburzeń funkcji rozrodczych u ludzi, w tym również u pacjentów z otyłością i cukrzycą.

EN

Only a decade ago metastin was known for its role in preventing metastasis. In 2003 this peptide was rediscovered as a group of peptides (10-54 amino acids in length) called kisspeptin, which are revolutionizing the field of reproductive biology. Kisspeptin plays a crucial role in regulation of puberty and other reproductive functions as well as pathological conditions, such as obesity and diabetes type 1 and 2, where there occur deregulation of the hypothalamic-pituitary-gonadal axis. As obesity and diabetes spread throughout the globe, the World Health Organization recognized both diseases as the major public health problems. In the United States, the obesity is already a serious health concern for one in three inhabitants. Thus, more attention is being paid to the correlation between increased body weight and impaired reproductive functions. Obesity is now dramatically on the rise and is a major risk factor for a number of chronic diseases, including diabetes. The accumulated so far evidence indicates that in the case of obesity and diabetes kisspeptin exhibits therapeutic effects on regulation of reproductive functions. Presence of kisspeptin peptides also in many other species (fish, amphibians, birds and mammals) allows the use of a variety of animal models. One can therefore expect further widening of the scope of experimental studies, especially since it has been shown recently that kisspeptin does not work alone, but cooperates with neurokinin B and dynorphin.

Keywords

PL

cukrzyca; kisspeptyna; oś podwzgórze-przysadka-gonady; otyłość; rozmnażanie

• Journal: Kosmos
• Year: 2016
• Volume: 65
• Issue: 2
• Pages: 217-225

Dates

published

2016

Contributors

author

Kamil Ziarniak

• Studenckie Koło Naukowe Zootechników i Biologów, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach, Uniwersytet Przyrodniczy w Poznaniu, Wołyńska 33, 60-637 Poznań, Polska
• Student's Association of Zootechnicians and Biologists, Faculty of Veterinary Medicine and Animal Sciences, Poznan University of Life Sciences, Wolynska 33, 60-637 Poznan, Poland

author

Monika Dudek

• Pracownia Neurobiologii, Instytut Zoologii, Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach, Wojska Polskiego 71 C, 60-625 Poznań, Polska
• Laboratory of Neurobiology, Institute of Zoology, Poznan University of Life Sciences, Faculty of Veterinary Medicine and Animal Sciences, Wojska Polskiego 71 C, 60-625 Poznan, Poland

author

Joanna Śliwowska

• Pracownia Neurobiologii, Instytut Zoologii, Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach, Wojska Polskiego 71 C, 60-625 Poznań, Polska
• Laboratory of Neurobiology, Institute of Zoology, Poznan University of Life Sciences, Faculty of Veterinary Medicine and Animal Sciences, Wojska Polskiego 71 C, 60-625 Poznan, Poland

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