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2017 | 64 | 2 | 371-374
Article title

E2F site in the essential promoter region does not confer S phase-specific transcription of the ABCC10 gene in human prostate cancer cells

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EN
Abstracts
EN
ABCC10 (MRP7) plays a role in cellular detoxification and resistance to anticancer drugs. Since ABCC10 gene transcription in human prostate cancer CWR22Rv1 cells was found dependent on E2F binding sequence motif, ABCC10 expression in G1 and S phases of the cell cycle of CWR22Rv1 cells, was analyzed. The cells were synchronized in G1 phase by double thymidine block and in S phase by thymidine/mimosine double block. ABCC10 mRNA level was found to be similar in S phase-synchronized and asynchronous cell populations. In G1 phase it decreased by 2.4- to 3-fold. It is thus inferred, that ABCC10 expression in CWR22Rv1 cells is not S phase-specific but is primarily associated with cell proliferation.
Keywords
Publisher

Year
Volume
64
Issue
2
Pages
371-374
Physical description
Dates
published
2017
received
2017-02-01
revised
2017-03-28
accepted
2017-03-29
(unknown)
2017-06-13
Contributors
  • Laboratory of Molecular Basis of Ageing, Department of Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warszawa, Poland
  • Memorial Sloan-Kettering Cancer Center, New York, NY10021, USA.
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv64p371kz
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