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2004 | 51 | 1 | 223-229
Article title

The mystery of reactive oxygen species derived from cell respiration.

Content
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Languages of publication
EN
Abstracts
EN
Mitochondrial respiration is considered to provide reactive oxygen species (ROS) as byproduct of regular electron transfer. Objections were raised since results obtained with isolated mitochondria are commonly transferred to activities of mitochondria in the living cell. High electrogenic membrane potential was reported to trigger formation of mitochondrial ROS involving complex I and III. Suggested bioenergetic parameters, starting ROS formation, widely change with the isolation mode. ROS detection systems generally applied may be misleading due to possible interactions with membrane constituents or electron carriers. Avoiding these problems no conditions reported to transform mitochondrial respiration to a radical source were confirmed. However, changing the physical membrane state affected the highly susceptible interaction of the ubiquinol/bc1 redox complex such that ROS formation became possible.
Year
Volume
51
Issue
1
Pages
223-229
Physical description
Dates
published
2004
received
2003-11-10
revised
2004-01-12
accepted
2004-01-13
References
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv51i1p223kz
Identifiers
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