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2001 | 48 | 3 | 739-744
Article title

Inhibition of the helicase activity of HCV NTPase/helicase by 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide-5'-triphosphate (ribavirin-TP).

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EN
Abstracts
EN
In the presented study the ribavirin-TP - an established inhibitor of the NTPase activity of the superfamily NTPase/helicases II - was investigated as an inhibitor of the unwinding activity of the hepatitis C virus (HCV) NTPase/helicase. The kinetics of the reaction revealed that ribavirin-TP reduces the turnover number of the helicase reaction by a mechanism that does not correspond to that of the inhibition of the NTPase activity. Our results suggest that derivatives of ribavirin-TP with enhanced stability towards hydrolytic attack may be effective inhibitors of the enzyme.
Publisher

Year
Volume
48
Issue
3
Pages
739-744
Physical description
Dates
published
2001
received
2001-01-8
revised
2001-04-4
accepted
2001-07-4
Contributors
  • Abteilung für Virologie, Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany
author
  • Abteilung für Virologie, Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany
  • Abteilung für Virologie, Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany
  • Abteilung für Virologie, Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany
  • Abteilung für Virologie, Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany
  • Klinik und Poliklinik Innere Medizin, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
author
  • Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejeon, Korea
  • Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland
  • Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv48i3p739kz
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