PL EN


Preferences help
enabled [disable] Abstract
Number of results
2009 | 81 | 1 | 68-74
Article title

Technical and Immunological Aspects of Face Transplantation

Content
Title variants
Languages of publication
EN
Abstracts
EN
The interest in facial transplantation led to development of many experimental models and novel immunosuppressive protocols. These studies allowed testing the immunological response to immunosuppressive protocols, and tolerance induction studies with supportive cell based therapies in composite tissues allograft transplants.In this article we present our experience with face transplantation models developed in our laboratory. We also summarize immunological responses and different immunosuppressive protocols used for tolerance induction through donor chimerism.
Publisher
Year
Volume
81
Issue
1
Pages
68-74
Physical description
Dates
published
1 - 1 - 2009
online
20 - 3 - 2009
References
  • Gibson T, Medawar PB: The fate of skin homografts in man. J Anat 1943; 77(Pt 4): 299-310.[PubMed]
  • Siemionow M, Gozel-Ulusal B, Engin UA et al.: Functional tolerance following face transplantation in the rat. Transplantation 2003; 75(9): 1607-09.[Crossref][PubMed]
  • Ulusal BG, Ulusal AE, Ozmen S et al.: A new composite facial and scalp transplantation model in rats. Plast Reconstr Surg 2003; 112(5): 1302-11.[Crossref]
  • Unal S, Agaoglu G, Zins J et al.: New surgical approach in facial transplantation extends survival of allograft recipients. Ann Plast Surg 2005; 55(3): 297-303.[Crossref]
  • Demir Y, Ozmen S, Klimczak A et al.: Tolerance induction in composite facial allograft transplantation in the rat model. Plast Reconstr Surg 2004; 114(7): 1790-1801.[PubMed][Crossref]
  • Yazici I, Carnevale K, Klimczak A et al.: A new rat model of maxilla allotransplantation. Ann Plast Surg 2007; 58(3): 338-44.[PubMed][Crossref][WoS]
  • Yazici I, Unal S, Siemionow M: Composite hemiface/calvaria transplantation model in rats. Plast Reconstr Surg 2006; 118(6): 1321-27.[Crossref][PubMed][WoS]
  • Gorantla VS, Barker JH, Jones JW Jr. et al.: Immunosuppressive agents in transplantation: mechanisms of action and current anti-rejection strategies. Microsurgery 2000; 20(8): 420-29.[Crossref]
  • Barratt-Boyes SM, Thomson AW: Dendritic cells: tools and targets for transplant tolerance. Am J Transplant 2005; 5(12): 2807-13.[Crossref]
  • Wilson NS, El-Sukkari D, Belz GT et al.: Most lymphoid organ dendritic cell types are phenotypically and functionally immature. Blood 2003; 102(6): 2187-94.[PubMed][Crossref]
  • Clavijo-Alvarez JA, Hamad GG, Taieb A et al.: Pharmacologic approaches to composite tissue allograft. J Hand Surg [Am.] 2007; 32(1): 104-18.[WoS][Crossref]
  • Siemionow MZ, Izycki DM, Zielinski M: Donorspecific tolerance in fully major histocompatibility major histocompatibility complex-mismatched limb allograft transplants under an anti-alphabeta T-cell receptor monoclonal antibody and cyclosporine A protocol. Transplantation 2003; 76(12): 1662-68.[Crossref]
  • Siemionow M, Ozer K, Izycki D et al.: A new method of bone marrow transplantation leads to extension of skin allograft survival. Transplant Proc 2005; 37(5): 2309-14.[PubMed][Crossref]
  • Siemionow M, Izycki D, Ozer K et al.: Role of thymus in operational tolerance induction in limb allograft transplant model. Transplantation 2006; 81(11): 1568-76.[PubMed][Crossref]
  • Kirk AD, Hale DA, Mannon RB et al.: Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H). Transplantation 2003; 76(1): 120-29.
  • Mariat C, Alamartine E, Diab N et al.: A randomized prospective study comparing low-dose OKT3 to low-dose ATG for the treatment of acute steroidresistant rejection episodes in kidney transplant recipients. Transpl Int 1998; 11(3): 231-36.
  • Thompson JS, Pomeroy C, Kryscio RJ et al.: Use of a T cell-specific monoclonal antibody, T10B9, in a novel allogeneic stem cell transplantation protocol for hematologic malignancy high-risk patients. Biol Blood Marrow Transplant 2004; 10(12): 858-66.[Crossref]
  • Starzl TE, Demetris AJ, Murase N et al.: Cell migration, chimerism, and graft acceptance. Lancet 1992; 339(8809): 1579-82.
  • Starzl TE, Demetris AJ: Transplantation tolerance, microchimerism, and the two-way paradigm. Theor Med Bioeth 1998; 19(5): 441-55.[PubMed][Crossref]
  • Starzl TE, Zinkernagel RM: Antigen localization and migration in immunity and tolerance. N Engl J Med 1998; 339(26): 1905-13.
  • Siemionow M, Demir Y, Mukherjee A et al.: Development and maintenance of donor-specific chimerism in semi-allogenic and fully major histocompatibility complex mismatched facial allograft transplants. Transplantation 2005; 79(5): 558-67.[PubMed][Crossref]
  • Bos JD: The skin as an organ of immunity. Clin Exp Immunol 1997; 107 (Suppl 13-5).
  • Bos JD, Zonneveld I, Das PK et al.: The skin immune system (SIS): distribution and immunophenotype of lymphocyte subpopulations in normal human skin. J Invest Dermatol 1987; 88(5): 569-73.[PubMed][Crossref]
  • Sminia T, Swart SJ, Steenbergen JJ et al.: Lymphoid tissue in rat oral mucosa: structure and function. Immunol. Cell Biol 1992; 70 (Pt 1): 33-40.
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_v10035-009-0009-x
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.