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2012 | 18 | 1 | 11-21
Article title

Establishment of in vitro 192Ir γ-ray dose-response relationship for dose assessment by the lymphocyte dicentric assay

Content
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EN
Abstracts
EN
In vitro dose-response relationships are used to describe the relation between dicentric chromosomes and radiation dose for human peripheral blood lymphocytes. The dicentric yield depends on both the dose and the radiation quality. Thus, for reliable dose estimation in vitro dose responses must be determined for different radiation qualities. This paper reports the work for setting up the relationship for the dicentric production in the lymphocytes exposed in vitro to 192Ir g-rays at Central Laboratory for Radiological Protection (CLOR). In a case of a radiation accident in industrial radiography using 192Ir sealed sources, this will be the basis for the indirect evaluation of the g-ray dose to which an accidental victim was exposed.
Publisher

Year
Volume
18
Issue
1
Pages
11-21
Physical description
Dates
published
1 - 03 - 2012
online
26 - 02 - 2013
Contributors
  • Central Laboratory for Radiological Protection Konwaliowa 7, 02-194 Warsaw, Poland, kowalska@clor.waw.pl
  • Central Laboratory for Radiological Protection Konwaliowa 7, 02-194 Warsaw, Poland
  • Central Laboratory for Radiological Protection Konwaliowa 7, 02-194 Warsaw, Poland
References
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  • [7] IAEA. (2001). Cytogenetic analysis for radiation dose assessment. A Manual. Technical Report 405. (Vienna: International Atomic Energy Agency).
  • [8] ICRU. (1980). Linear Energy Transfer. Report 6. Washington DC. International Commission on Radiological Units.
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  • [10]Papworth DG (1975). Curve fitting by maximum likelihood. Appendix to paper by JRK Savage, Radiation induced chromosomal aberrations in the plant Trasdescantia. Dose-response curves. Radiat. Botanic, 15, 87.
  • [11]Savage JRK and Papworth DG. (2000). Constructing a 2B calibration curve for retrospective dose reconstruction. Radiat. Prot. Dosim, 88, 69-76.
  • [12]Sevan’kaev AV, Lloyd DC, Edwards AA, Moquet JE, Nugis VYu, Mikhailova GM, Potetnaya OI, Khvostunov IK, Guskova AK, Baranow AE and Nadejina NM (2002). Cytogenic investigations of serious overexposure to industrial gamma radiography source. Radiat. Prot. Dosim, 102, 201-206.
  • [13]Sreedevi B., Rao BS and Bhatt B. (1993). Radiation-induced chromosome aberration yields following an accidental non-uniform exposure. Radiat. Prot. Dosim, 50, 45-49.
  • [14]Szłuińska M, Edwards D, Lloyd D (2007). Presenting statistical uncertainty on cytogenetic dose estimates. Radiat. Prot. Dosim, 123, 443-449.[WoS]
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_v10013-012-0003-1
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