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2013 | 8 | 3 | 354-357

Article title

Urine saturation and promoter/inhibitor parameters and ratios in renal stone disease caused by ceftriaxone


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During ceftriaxone treatment of subdural empyema caused by Streptococcus intermedius urinary and biliary stones were noticed. Increased levels of urinary calcium excretion were detected during ongoing treatment in comparison with 2 months check-up. There were no significant changes in the promoter/inhibitor urolithiasis parameters, oxalate, citrate, urate, cistine, glycosaminoglycans or their ratios. Urine saturation was calculated using EQUIL 2 computer programme (calcium oxalate, brushite) and it was normal. Probable trigger for the ceftriaxone/calcium hydroxy carbonate phosphate mixture of stones was a critical boost of solubility products caused by ceftriaxone treatment and phospnate urine content with a subsequent large-scale spontaneous precipitation of crystals.










Physical description


1 - 6 - 2013
17 - 4 - 2013


  • Department for Pediatric Nephrology, University Children’s Hospital Zagreb, Zagreb School of Medicine, Kišpatićeva 12, 10000, Zagreb, Croatia
  • Department for Pediatric Infectious diseases, School of Medicine, Zagreb University, Zagreb, Croatia
  • Department for Physical chemistry, Institute „Ruđer Bošković“, Bijenička cesta 54, 10000, Zagreb, Croatia
  • Department of Anesthesiology and Intesive Care, University Clinical Centre Zagreb, Zagreb, Croatia
  • Department for Pediatric Nephrology, University Children’s Hospital Zagreb, Zagreb School of Medicine, Kišpatićeva 12, 10000, Zagreb, Croatia
  • Department for Pediatric Nephrology, University Children’s Hospital Zagreb, Zagreb School of Medicine, Kišpatićeva 12, 10000, Zagreb, Croatia
  • Department for Pediatric Nephrology, University Children’s Hospital Zagreb, Zagreb School of Medicine, Kišpatićeva 12, 10000, Zagreb, Croatia


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