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2011 | 6 | 1 | 107-112

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Association between Helicobacter. pylori and coronary artery disease


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The high prevalence of both Helicobacter.pylori infection and coronary atherosclerosis in our country prompted us to assess the probable association between both conditions. This cross-sectional study recruited 153 patients scheduled to undergo coronary artery angiography. Patients were divided into two groups on the basis of coronary angiography results. Sixty-nine patients had coronary atherosclerosis and the 84 remaining patients were normal. Characteristics and pre-angiographic serum levels of triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein, and Helicobacter.pylori IgG antibody were assessed in the patients and compared between the groups. Helicobacter.pylori infection occurred in 88 (57.51%) patients: 40 (58%) in the atherosclerotic group and 48 (57.1%) in the control group with no significant differences (P=0.918). Our multivariable analysis revealed that Helicobacter.pylori infection was not an independent predictive factor for coronary artery disease (P =0.915). Also, the prevalence of atherosclerosis risk factors with respect to the seropositive and seronegative Helicobacter.pylori infection was assessed in the case group, which showed no significant difference. Furthermore, the prevalence of seropositive Helicobacter.pylori infection in terms of the number of diseased coronary vessels was evaluated, this demonstrated no significant association between the number of the diseased vessels and Helicobacter.pylori infection. This study demonstrated that Helicobacter.pylori infection was not an independent predictive factor of atherosclerosis.










Physical description


1 - 2 - 2011
16 - 12 - 2010


  • Infectious Diseases Department, Imam Khomeini Hospital, Tehran University of Medical Sciences, 1411713138, Tehran, Iran
  • Cardiovascular Surgery Department, Tehran Heart Center, Tehran University of Medical Sciences, 1411713138, Tehran, Iran
  • Pathology & Laboratory Medicine Department, Tehran Heart Center, Tehran University of Medical Sciences, 1411713138, Tehran, Iran
  • Infectious Diseases Department, Imam Khomeini Hospital, Tehran University of Medical Sciences, 1411713138, Tehran, Iran
  • Clinical research Department, Tehran Heart Center, Tehran University of Medical Sciences, 1411713138, Tehran, Iran


  • [1] Tabatabaei Yazdi SA, Rezaei A, Bordbar Azari J, Hejazi A, Shakeri MT, Karimi Shahri M. Prevalence of Atherosclerotic Plaques in Autopsy Cases with Noncardiac Death. Iranian Journal of Pathology 2009; 4: 101–104
  • [2] Kadar A, Glasz T. Development of atherosclerosis and plaque biology. Cardiovasc Surg 2001; 9:109–21 http://dx.doi.org/10.1016/S0967-2109(00)00097-1[Crossref]
  • [3] Pasceri V, Cammarota G, Patti G, Cuoco L, Gasbarrini A, Grillo RL, Fedeli G, Gasbarrini G, Maseri A. Association of virulent Helicobacter pylori strains with ischaemic heart disease. Circulation 1998; 97:1675–9 [Crossref][PubMed]
  • [4] Ridker PM, Danesh J, Youngman L, Collins R, Stampfer MJ, Peto R, Hennekens CH. A prospective study of Helicobacter pylori seropositivity and the risk for future myocardial infarction among socioeconomically similar U.S. men. Ann Intern Med 2001; 135:184–8
  • [5] Stone AF, Risley P, Markus HS, Butland BK, Strachan DP, Elwood PC, Mendall MA. Ischaemic heart disease and Cag A strains of Helicobacter pylori in the Caerphilly heart disease study. Heart 2001; 86: 506–9 http://dx.doi.org/10.1136/heart.86.5.506[Crossref]
  • [6] Patel P, Mendall MA, Carrington D, Strachan DP, Leatham E, Molineaux N, J Levy, C Blakeston, C A Seymour, A J Camm, T C Northfield. Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors. BMJ 1995; 311: 711–714 [Crossref]
  • [7] Murray LJ, Bamford KB, Kee F, McMaster D, Cambien F, Dallongeville J, Evans A. Infection with virulent strains of Helicobacter pylori is not associated with ischaemic heart disease: evidence from a populationbased case-control study of myocardial infarction. Atherosclerosis 2000; 149:379–85 http://dx.doi.org/10.1016/S0021-9150(99)00325-1[Crossref]
  • [8] Zhu J, Quyyumi AA, Muhlestein JB, Nieto FJ, Horne BD, Zalles-Ganley A, Anderson JL, Epstein SE. Lack of association of Helicobacter pylori infection with coronary artery disease and frequency of acute myocardial infarction or death. Am J Cardiol 2002; 89:155–8 http://dx.doi.org/10.1016/S0002-9149(01)02192-0[Crossref]
  • [9] Bazzazi H, Ramezani M.A, Bazoori M, Mohamadi Bondarkheili A, ArabAhmadi M, Ghaemi E. Seroepidemiology of Helicobacter Pylori infection in Patients with coronary syndrome in Gorgan. Medical Laboratory Journal 2007; 1: 33–37
  • [10] Dunn BE, Cohen H, Blaser MJ. Helicobacter pylori. Clin Microbiol Rev 1997; 10:720–41 [PubMed]
  • [11] Thoreson AC, Borre M, Andersen LP, Jorgensen F, Kiilerich S, Scheibel J, Rath J, Krogfelt KA.. Helicobacter pylori detection in human biopsies: a competitive PCR assay with internal control reveals false results. FEMS Immunol Med Microbiol 1999; 24: 201–8 http://dx.doi.org/10.1111/j.1574-695X.1999.tb01283.x[Crossref]
  • [12] Arias E, Martinetto H, Schultz M, Ameriso S, Rivera S, Lossetti O, Sevlever G. Seminested Polymerase Chain Reaction (PCR) for Detecting Helicobacter pylori DNA in Carotid Atheromas. Diagn Mol Pathol 2006; 15:174–179 http://dx.doi.org/10.1097/01.pdm.0000213454.45398.2e[Crossref]
  • [13] Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002; 347: 1175–86 http://dx.doi.org/10.1056/NEJMra020542[Crossref]
  • [14] Rahnama B, Zadegan N, Fatahi E, Samadi Khah J. Survey On The Association Of Seropositivity Of H.Pylori IgG With Acute Myocardial Infarction. Journal of Kerman University of Medical Sciences 2001; 8: 66–73 [abstract in English]
  • [15] Aghajani CM, Abbasian M. Association of Helicobacter pylori infection and its Cag A-positive strains with coronary heart disease. Journal of Tebe Jonob 2002; 1: 62–65 [abstract in English]
  • [16] Folsom AR, Nieto FJ, Sorlie P, Chambless LE, Graham DY. Helicobacter pylori seropositivity and coronary heart disease incidence: Atherosclerosis Risk In Communities (ARIC) Study Investigators. Circulation 1998; 98: 845–850 [Crossref]
  • [17] Stollberger C, Molzer G, Finsterer J. Seroprevalence of antibodies to microorganisms known to cause arterial and myocardial damage in patients with or without coronary stenosis. Clin Diagn Lab Immunol 2001; 8: 997–1002
  • [18] Tasi CJ, Huang TY. Relation of Helicobacter pylori infection and angiographically demonstrated coronary artery disease. Dig Dis Sci 2000; 45:1227–32 http://dx.doi.org/10.1023/A:1005522624004[Crossref]
  • [19] Carlsson J, Miketic S, Brom J, Ross R, Bachmann H, Tebbe U. Prior cytomegalovirus, Chlamydia pneumoniae or Helicobacter pylori infection and the risk of restenosis after percutaneous transluminal coronary angioplasty. Int J Cardiol 2000; 73:165–71 http://dx.doi.org/10.1016/S0167-5273(00)00216-3[Crossref]
  • [20] Biagi P, Fabbrini D, Bocchini S. Seroprevalence of Helicobacter pylori infection in a group of hospitalized geriatric patients. Panminerva Med 2000; 42:183–6[Abs]
  • [21] Danesh J, Wong Y, Ward M, Muir J. Chronic infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus: population based study of coronary heart disease. Heart 1999; 81:245–7 [Crossref]
  • [22] Mendall MA, Goggin PM, Molineaux N, Levy J, Toosy T, Strachan D, Camm AJ, Northfield TC. Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J 1994; 71:43–79 http://dx.doi.org/10.1136/hrt.71.5.437[Crossref]
  • [23] Alkout AM, Ramsay EJ, Mackenzie DA, Weir DM, Bentley AJ, Elton RA, Sutherland S, Busuttil A, Blackwell CC. Quantitative assessment of IgG antibodies of Helicobacter pylori and outcome of ischaemic heart disease. FEMS Immunol Med Microbiol 2002; 29:271–4 http://dx.doi.org/10.1111/j.1574-695X.2000.tb01533.x[Crossref]
  • [24] Pellicano R, Mazzarello MG, Morelloni S, Allegri M, Arena V, Ferrari M, Rizzetto M, Ponzetto A. Acute myocardial infarction and Helicobacter pylori seropositivity. Int J Clin Lab Res 1999; 29:141–4 http://dx.doi.org/10.1007/s005990050080[Crossref]
  • [25] Danesh J, Youngman L, Clark S, Parish S, Peto R, Collins R. Helicobacter pylori infection and early onset myocardial infarction: case-control and sibling pairs study. Br Med J 1999; 319:1157–62
  • [26] Pieniazek P, Karczewska E, Duda A, Tracz W, Pasowicz M, Konturek SJ. Association of Helicobacter pylori infection with coronary heart disease. J Physiol Pharmacol 1999; 50:743–51
  • [27] Kanbay M, Gur G, Yucel M, Muderrisoglu H. Helicobacter pylori sero prevalence in patients with coronary artery disease. Digestive Diseases and Sciences 2005 Nov;50(11):2071–2074 http://dx.doi.org/10.1007/s10620-005-3009-7[Crossref]
  • [28] Kowalski M, Kunturek PC, Karczewska E, Karczewska E, Kluczka A, Grove R, Kranig W, Nasseri R, Thale J, Hahn EG, Konturek SJ. Prevalence of helicobacter pylori infection in coronary artery disease and effect of its eradication on coronary lumen reduction after perecutaneous coronary angioplasty. Digest Liver Dis 2001:33:222–9 http://dx.doi.org/10.1016/S1590-8658(01)80711-8[Crossref]
  • [29] Marrollo M, Latella G, Melideo D, Storelli E, Iannarelli R, Stornelli P, Valenti M, Caprilli R. Increased prevalence of Helicobacter pylori in patients with diabetes mellitus. Dig Liver Dis 2001; 33: 21–29 http://dx.doi.org/10.1016/S1590-8658(01)80131-6[Crossref]
  • [30] Lip GH, Wise R, Beevers G. Association of Helicobacter pylori infection with coronary heart disease: Study shows association between H. pylori infection and hypertension. BMJ 1996; 312: 250–251 [Crossref]
  • [31] Harvey R, Lane A, Murray L, Harvey I, Nair P, Donovan J. Effect of Helicobacter pylori infection on blood pressure: A community based cross sectional study. BMJ 2001; 323: 264–265 http://dx.doi.org/10.1136/bmj.323.7307.264[Crossref]
  • [32] Ekesbo R, Nilsson PM, Lindholm LH, Persson K, Wadstrom T. Combined seropositivity for H. pylori and C. pneumoniae is associated with age, obesity and social factors. J Cardiovasc Risk 2000; 7:191–195
  • [33] Niemela S, Karttunen T, Korhonen T, Laara E, Karttunen R, Ikaheimo M, Kesäniemi YA. Could Helicobacter pylori infection increase the risk of coronary heart disease by modifying serum lipid concentrations? Heart1996; 75: 573–575 http://dx.doi.org/10.1136/hrt.75.6.573[Crossref]
  • [34] Lu YH, Yen HW, Lin TH, Huang CH, Lee KT, Wang WM, Wu DC, Voon WC, Lai WT, Sheu SH. Changes of coronary risk factors after eradication of Helicobacter pylori infection. Kaohsiung J Med Sci 2002; 18:266–72. [Abs] [WoS]
  • [35] Singh RK, McMahon AD, Patel H, Packard CJ, Rathbone BJ, Samani NJ. Prospective analysis of the association of infection with CagA bearing strains of Helicobacter pylori and coronary heart disease. Heart 2002; 88:43–6 http://dx.doi.org/10.1136/heart.88.1.43[Crossref]
  • [36] Pellicano R, Parravicini PP, Bigi R, Gandolfo N, Aruta E, Gai V, Figura N, Angelino P, Rizzetto M, Ponzetto A. Infection by Helicobacter pylori and acute myocardial infarction. Do cytotoxic strains make a difference? New Microbiol 2002; 25:315–21

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