Eordaia basin located in northwest of Greece, comprises an area which is characterized by intense energy related activities, including coal burning at four power plants and the associated mining operations. Air samples of inhalable (PM10) and respirable particles (PM2.5) were collected in cold and warm periods in 2010 at an urban background site of Kozani, the major city and capital of the region which is located close to the power plants. Particulate matter concentration, particle-bound polycyclic aromatic hydrocarbons and anionic species concentrations were determined using gravimetric, GC-MS in SIM mode and Ion Chromatography analysis, respectively. For the cold period, the mean PM10 and PM2.5 mass concentration was found to be 19.62 and 14.68 µg m−3, respectively. Correspondingly, for the warm period, the mean PM10 and PM2.5 values were 35.29 and 25.75 µg m−3, respectively. In general, the results indicated that the major sources of air pollution in Kozani are traffic, combustion from agricultural activities and lignite power plants emissions, contributing by different percentages to each particle fraction.