PL EN


Preferences help
enabled [disable] Abstract
Number of results
Journal
2013 | 11 | 12 | 2040-2047
Article title

UV-absorption studies of interaction of karanjin and karanjachromene with ds. DNA: Evaluation of binding and antioxidant activity

Content
Title variants
Languages of publication
EN
Abstracts
EN
Two flavonoids, karanjin (Kj) and karanjachromene (Kc) have been investigated spectrophotometrically for their mode of interactions with double stranded (ds)-DNA at blood (7.4) and stomach (4.7) pH and at human body temperature (37°C). Benesi-Hildebrand equation was used to evaluate the binding constants, K b . Binding constants at both pH values and at body temperature showed stronger binding of both the flavonoids and formation of 1:1 flavonoid-DNA complex via intercalative mode. However, K b values for karanjin were evaluated to be comparatively greater than karanjachromene at both pH values. The highest value of binding constant (1.32×105 M−1) for karanjin at blood pH (7.4) demonstrated its comparatively stronger binding and greater effectiveness at this pH. Standard Gibbs free energy changes (ΔG) of flavonoid-DNA complexes were calculated as negative values and indicative of spontaneity of their binding. Both flavonoids showed significant DNA protection activity. [...]
Publisher
Journal
Year
Volume
11
Issue
12
Pages
2040-2047
Physical description
Dates
published
1 - 12 - 2013
online
26 - 9 - 2013
References
  • [1] N. Arshad, N.K. Janjua, L.H. Skibsted, M.L. Anderson, J. Chem. Soc. Pak. 35, 544 (2013)
  • [2] N. Arshad, N.K. Janjua, A.Y. Khan, J.H. Zaidi, L.H. Skibsted, Monatsh. Chem. 143, 377 (2012) http://dx.doi.org/10.1007/s00706-011-0606-3[Crossref]
  • [3] N. Arshad, N.K. Janjua, A.Y. Khan, A. Yaqub, T. Burkholz, C. Jacob, Nat. Prod. Commun. 7, 311 (2012)
  • [4] N. Arshad, N.K. Janjua, S. Ahmed, A.Y. Khan, L.H. Skibsted, Electrochem. Acta 54, 6184 (2009) http://dx.doi.org/10.1016/j.electacta.2009.05.087[Crossref]
  • [5] K.Y. Akhilesh, T. Jayprakash, P. Om, K. Feroz, S. Dharmendra, M.G. Madan, Med. Chem. Res. 22, 2706 (2013) http://dx.doi.org/10.1007/s00044-012-0268-7[Crossref]
  • [6] L. Malyane, W.K. Benguedouar, H.N. Boussenane, H. Rouibah, M. Lahouel, Pak. J. Pharm. Sci. 21, 201 (2008)
  • [7] A.R. Tapas, D.M. Sakarkar, R.B. Kakde, Trop. Pharm. Res. 7, 1089 (2008)
  • [8] R.J. Nijveldt, E.V. Nood, D.E.C.V. Hoorn, P.G. Boelens, K.V. Norren, P.A.M.V. Leeuwen, Am. J. Clin. Nutr. 74, 418 (2001)
  • [9] N. Rashid, M.S.A. Abbassi, M.K. Tahir, N.M. Yusof, B.M. Yamin, Anal. Sc. 24, x21 (2008)
  • [10] K.L. Sahrawat, J. Ind. Soc. Soil Sci. 30, 156 (1982)
  • [11] K.L. Sahrawat, S.K. Mukherjee, Plant Soil 47, 27 (1997) http://dx.doi.org/10.1007/BF00010365[Crossref]
  • [12] G. Ahmad, P.K. Mishra, P. Gupta, P.P. Yadav, P. Tiwari, A.K. Tamrakar, A.K. Srivastava, R. Maurya, Bioorg. Med. Chem. Lett. 16, 2139 (2006) http://dx.doi.org/10.1016/j.bmcl.2006.01.062[Crossref]
  • [13] S.L. Badole, S.L. Bodhankar, J. Ethnopharmacol. 123, 115 (2009) http://dx.doi.org/10.1016/j.jep.2009.02.018[Crossref]
  • [14] A.K. Tamrakar, P.P. Yadav, P. Tiwari, R. Maurya, A.K. Srivastava, J. Ethnopharmacol. 118, 435 (2008) http://dx.doi.org/10.1016/j.jep.2008.05.008[Crossref]
  • [15] D. Majumdar, Chemosphere 47, 845 (2002) http://dx.doi.org/10.1016/S0045-6535(01)00287-9[Crossref]
  • [16] K. Simin, Z. Ali, S.M.K. Zaman, V.U. Ahmad, Nat. Prod. Lett. 16, 351 (2002) http://dx.doi.org/10.1080/10575630290033114[Crossref]
  • [17] H. Wiseman, B. Halliwell, Biochem. J. 313, 17 (1996)
  • [18] V.C. Diculescu, A.M.C.A. Paquim, M.O. Brett, Sensors 5, 377 (2005) http://dx.doi.org/10.3390/s5060377[Crossref]
  • [19] S.W.P. Wijnhoven, H.V. Steeg, Toxicology 193, 171 (2003) http://dx.doi.org/10.1016/S0300-483X(03)00295-6[Crossref]
  • [20] S. Jun, Int. J. Chem. 2, 261 (2010)
  • [21] L.H. Breimer, Br. J. Cancer 57, 6 (1988) http://dx.doi.org/10.1038/bjc.1988.2[Crossref]
  • [22] M. Aslanoglu, N. Oge, Turk. J. Chem. 29, 477 (2005)
  • [23] P.G. Baraldi, et al., Med. Res. Rev. 24, 475 (2004) http://dx.doi.org/10.1002/med.20000[Crossref]
  • [24] N. Li, Y. Ma, C. Yang, L. Guo, X. Yang, Biophys. Chem. 116, 199 (2005) http://dx.doi.org/10.1016/j.bpc.2005.04.009[Crossref]
  • [25] J. Sambrook, E.F. Fritsch, T. Maniatis, Molecular cloning: a laboratory manual (Cold Spring Harbor, New York, 1989)
  • [26] M.E. Reichmann, S.A. Rice, C.A. Thomas, P. Doty, J. Am. Chem. Soc. 76, 3047 (1954) http://dx.doi.org/10.1021/ja01640a067[Crossref]
  • [27] S.S. Babkina, N.A. Ulakhovich, Anal. Chem. 77, 5678 (2005) http://dx.doi.org/10.1021/ac050727b[Crossref]
  • [28] B. Yang, A. Kotani, K. Arai, F. Kusu, Anal. Sci. 17, 599 (2001) http://dx.doi.org/10.2116/analsci.17.599[Crossref]
  • [29] L.G. Nest, O. Caille, M. Woudstra, S. Roche, B. Burlat, V. Belle, B. Guigliarelli, D. Lexa, Inorg. Chim. Acta 357, 2027 (2004) http://dx.doi.org/10.1016/j.ica.2003.11.046[Crossref]
  • [30] K.R. Markham, In Techniques of Flavonoid Identification (Academic Press, London, 1982) 16
  • [31] N.K. Janjua, A. Siddiqa, A. Yaqub, S. Sabahat, R. Qureshi, S, Haque, Spectrochim. Acta Part A 74, 1135 (2009) http://dx.doi.org/10.1016/j.saa.2009.09.022[Crossref]
  • [32] G.J. Yang, J.J. Xu, H.Y. Chen, Z.Z. Leng, Chin. J. Chem. 22, 1325 (2004) http://dx.doi.org/10.1002/cjoc.20040221122[Crossref]
  • [33] Y. Sun, S. Bi, D. Song, C. Qiao, D. Mu, H. Zhang, Sensors and Actuators B 129, 799 (2008) http://dx.doi.org/10.1016/j.snb.2007.09.082[Crossref]
  • [34] M. Aslanoglu, Anal. Sci. 22, 439 (2006) http://dx.doi.org/10.2116/analsci.22.439[Crossref]
  • [35] E.C. Long, J.K. Barton, Acc. Chem. Res. 23, 271 (1990) http://dx.doi.org/10.1021/ar00177a001[Crossref]
  • [36] A. Tarushi, C.P. Raptopoulou, V, Psycharis, A. Terzis, G. Psomas, D.P. Kessissoglou, Bioorg. Med. Chem. 18, 2678 (2010) http://dx.doi.org/10.1016/j.bmc.2010.02.021[Crossref]
  • [37] G. Pratviel, J. Bernadou, B. Meunier, Adv. Inorg. Chem. 45, 251 (1998) http://dx.doi.org/10.1016/S0898-8838(08)60027-6[Crossref]
  • [38] A.J. Hobro, M. Rouhi, E.W. Blanch, G.L. Conn, Nucleic Acids Res. 35, 1169 (2007) http://dx.doi.org/10.1093/nar/gkm012[Crossref]
  • [39] J.J.B. Thomas, Biochim. Biophys. Acta 213, 417 (1970) http://dx.doi.org/10.1016/0005-2787(70)90049-3[Crossref]
  • [40] J.J. Niu, G.J. Cheng, S.J. Dong, Electrochim. Acta 39, 2455 (1994) http://dx.doi.org/10.1016/0013-4686(94)E0150-M[Crossref]
  • [41] N. Arshad, U. Yunus, S. Razzque, M. Khan, S. Saleem, B. Mirza, N. Rashid, Eur. J. Med. Chem. 47, 452 (2012). http://dx.doi.org/10.1016/j.ejmech.2011.11.014[Crossref]
  • [42] V. Vrchovska, C. Sousa, P. Valentaõ, F. Ferreres, J.A. Pereira. R.M. Seabra, P.B. Andrade, Food Chem. 98, 416 (2006) http://dx.doi.org/10.1016/j.foodchem.2005.06.019[Crossref]
  • [43] G.H. Naik, K.I. Priyadarsini, J.G. Satav, M.M. Banavalikar, D.P. Sohoni, M.K. Biyani, H. Mohan, Phytochem. 63, 97 (2003) http://dx.doi.org/10.1016/S0031-9422(02)00754-9[Crossref]
  • [44] M. Okawa, J. Kinjo, T. Nohara, M. ONO, Biol. Pharm. Bull. 24, 1202 (2001) http://dx.doi.org/10.1248/bpb.24.1202[Crossref]
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0327-z
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.