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Journal
2013 | 11 | 8 | 1309-1319
Article title

High resolution mass spectrometric characterization of amino linked oligosaccharides - a preliminary study

Content
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EN
Abstracts
EN
In this study maltose, maltotriose and maltotetraose were for the first time, coupled to 4,4′-methylenedianiline (MDA). The aim of this preliminary work was to test the feasibility of oligo- and polysaccharide coupling to MDA and the characterization of the coupling products by high resolution mass spectrometry (MS). (+) nanoESI in combination with a quadrupole time of flight (QTOF) MS in full scan (MS) and MS/MS was optimized first on underivatized maltose, maltotriose and maltotetraose. The optimal screening and sequencing conditions were further applied to the MDA-functionalized oligosaccharides. The obtained results revealed a straightforward MS detection of the functionalized oligomers, high sequence coverage and a fragmentation pathway with the formation of B and Y ions as well as the complementary C and Z ions along with a typical cleavage of the aglycon. We consider that this methodology is fully applicable also to polydisperse mixtures of long chain polysaccharides, which due to the large number of components and their size require a systematic method of development and testing. [...]
Publisher

Journal
Year
Volume
11
Issue
8
Pages
1309-1319
Physical description
Dates
published
1 - 8 - 2013
online
1 - 6 - 2013
Contributors
  • Department of Biochemistry, University of Medicine and Pharmacy “Victor Babes”, 300041, Timisoara, Romania
author
  • Department of Biochemistry, University of Medicine and Pharmacy “Victor Babes”, 300041, Timisoara, Romania
author
  • Department of Biochemistry, University of Medicine and Pharmacy “Victor Babes”, 300041, Timisoara, Romania
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0265-9
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