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Journal
2012 | 10 | 6 | 1842-1849
Article title

A simple and precise conductometric method for the determination of losartan in pharmaceutical products

Content
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EN
Abstracts
EN
Losartan is an antihypertensive agent that lost its patent protection in 2010, and, consequently, it has been available in generic form. The latter motivated the search for a rapid and precise alternative method. Here, a simple conductometric titration in aqueous medium is described for the losartan analysis in pharmaceutical formulations. The first step of the titration occurs with the protonation of losartan producing a white precipitate and resulting in a slow increase in conductivity. When the protonation stage is complete, a sharp increase in conductivity occurs which was determined to be due to the presence of excess of acid. The titrimetric method was applied to the determination of losartan in pharmaceutical products and the results are comparable with values obtained using a chromatographic method recommended by the United States Pharmacopoeia. The relative standard deviation for successive measurements of a 125 mg L−1 (2.71×10−4 mol L−1) losartan solution was approximately 2%. Recovery study in tablet samples ranged between 99 and 102.4%. The procedure is fast, simple, and represents an attractive alternative for losartan quantification in routine analysis. In addition, it avoids organic solvents, minimizes the risk of exposure to the operator, and the waste treatment is easier compared to classical chromatographic methods. [...]
Publisher

Journal
Year
Volume
10
Issue
6
Pages
1842-1849
Physical description
Dates
published
1 - 12 - 2012
online
21 - 9 - 2012
Contributors
  • Instituto de Química, Universidade de São Paulo, 748 CEP 05508-000, São Paulo, Brazil
author
  • Instituto de Química, Universidade de São Paulo, 748 CEP 05508-000, São Paulo, Brazil
author
  • Instituto de Química, Universidade de São Paulo, 748 CEP 05508-000, São Paulo, Brazil, luangnes@iq.usp.br
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-012-0110-6
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