A simple and precise conductometric method for the determination of losartan in pharmaceutical products

• Authors: Pamela Oliveira Rossini , Fabiana Felix , Lúcio Angnes
• Languages of publication: EN

Abstracts

EN

Losartan is an antihypertensive agent that lost its patent protection in 2010, and, consequently, it has been available in generic form. The latter motivated the search for a rapid and precise alternative method. Here, a simple conductometric titration in aqueous medium is described for the losartan analysis in pharmaceutical formulations. The first step of the titration occurs with the protonation of losartan producing a white precipitate and resulting in a slow increase in conductivity. When the protonation stage is complete, a sharp increase in conductivity occurs which was determined to be due to the presence of excess of acid. The titrimetric method was applied to the determination of losartan in pharmaceutical products and the results are comparable with values obtained using a chromatographic method recommended by the United States Pharmacopoeia. The relative standard deviation for successive measurements of a 125 mg L−1 (2.71×10−4 mol L−1) losartan solution was approximately 2%. Recovery study in tablet samples ranged between 99 and 102.4%. The procedure is fast, simple, and represents an attractive alternative for losartan quantification in routine analysis. In addition, it avoids organic solvents, minimizes the risk of exposure to the operator, and the waste treatment is easier compared to classical chromatographic methods. [...]

Keywords

EN

Antihypertensive agent; Conductometric method; Losartan potassium; Pharmaceutical products; Titrimetric procedures

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2012
• Volume: 10
• Issue: 6
• Pages: 1842-1849

Dates

published

1 - 12 - 2012

online

21 - 9 - 2012

Contributors

author

Pamela Oliveira Rossini

• Instituto de Química, Universidade de São Paulo, 748 CEP 05508-000, São Paulo, Brazil

author

Fabiana Felix

• Instituto de Química, Universidade de São Paulo, 748 CEP 05508-000, São Paulo, Brazil

author

Lúcio Angnes

• Instituto de Química, Universidade de São Paulo, 748 CEP 05508-000, São Paulo, Brazil

References

• [1] United States Pharmacopoeia (United States Pharmacopoeial Convention, Rockville, 2009)
• [2] R.D. Larsen, A.O. King, C.Y. Chen, E.G. Corley, B.S. Foster, F.E. Roberts, C.H. Yang, D.R. Lieberman, R.A. Reamer, D.M. Tschaen, T.R. Verhoeven, P.J. Reider, J. Org. Chem. 59, 6391 (1994) http://dx.doi.org/10.1021/jo00100a048[Crossref]
• [3] M.I. Toral, O.Y.M. Saldias, C Soto, Quim. Nova 32, 257 (2009) http://dx.doi.org/10.1590/S0100-40422009000100043[Crossref]
• [4] C. Alfarano, S. Suffredini, O. Fantappie, A. Mugelli, E. Cerbai, M.E. Manni, L. Raimondi, Pharm. Res. 63, 225 (2011) http://dx.doi.org/10.1016/j.phrs.2010.11.001[Crossref]
• [5] M.C. Salvadori, R.F. Moreira, B.C. Borges, M.H. Andraus, C.P. Azevedo, R.A. Moreno, N.C. Borges, Clin. Exp. Hypertens. 31, 415 (2009) http://dx.doi.org/10.1080/10641960802668714[Crossref]
• [6] R.C. Williams, M.S. Alasandro, V.L. Fasone, R.J. Boucher, J.F. J. Edwards, J. Pharm. Biomed. Anal. 14, 1539 (1996) http://dx.doi.org/10.1016/0731-7085(96)01740-2[Crossref]
• [7] K.E. McCarthy, Q.X. Wang, E.W. Tsai, R.E. Gilbert, D.P. Ip, M.A. Brooks, J. Pharm. Biomed. Anal. 17, 671 (1998) http://dx.doi.org/10.1016/S0731-7085(97)00251-3[Crossref]
• [8] O.C. Lastra, I.G. Lemus, H.J. Sanchez, R.F. Perez, J. Pharm. Biomed. Anal. 33, 175 (2003) http://dx.doi.org/10.1016/S0731-7085(03)00347-9[Crossref]
• [9] A.H. Prabhakar, R. J. Giridhar, J. Pharm. Biomed. Anal. 27, 861 (2002) http://dx.doi.org/10.1016/S0731-7085(01)00536-2[Crossref]
• [10] M. Ansari, M. Kazemipour, F. Khosravi, M. Baradaran, Chem. Pharm. Bull. 52, 1166 (2004) http://dx.doi.org/10.1248/cpb.52.1166[Crossref]
• [11] R. Bonfilio, C.R.T. Tarley, G.R. Pereira, H.R.N. Salgado, M.B. de Araujo, Talanta 80, 236 (2009) http://dx.doi.org/10.1016/j.talanta.2009.06.060[Crossref]
• [12] M. Polinko, K. Riffel, H.C. Song, M.W. Lo, J. Pharm. Biomed. Anal. 33, 73 (2003) http://dx.doi.org/10.1016/S0731-7085(03)00348-0[Crossref]
• [13] M.D. Brunetto, Y. Contreras, S. Clavijo, D. Torres, Y. Delgado, F. Ovalles, C. Ayala, M. Gallignani, J.M Estela, V.C. Martin, J. Pharm. Biomed. Anal. 50, 194 (2009) http://dx.doi.org/10.1016/j.jpba.2009.04.015[Crossref]
• [14] H.J. Shah, M.L. Kundlik, N.K. Patel, G. Subbaiah, D.M. Patel, B.N. Suhagia, C.N. Patel, J. Sep. Sci. 32, 3388 (2009) http://dx.doi.org/10.1002/jssc.200900287[Crossref]
• [15] E. Cagigal, L. Gonzalez, R.M. Alonso, R.M. Jimenez, Talanta 54, 1121 (2001) http://dx.doi.org/10.1016/S0039-9140(01)00379-4[Crossref]
• [16] F. Kolocouri, Y. Dotsikas, C. Apostolou, C. Kousoulos, Y.L. Loukas, Simultaneous determination of losartan, Anal. Bioanal. Chem. 387, 593 (2007) http://dx.doi.org/10.1007/s00216-006-0990-4[Crossref]
• [17] M.S. Arayne, N. Sultana, F. Qureshi, F.A. Siddiqui, A.Z. Mirza, S.S. Bahadur, M. Zuberi, Chromatographia 70, 789 (2009) http://dx.doi.org/10.1365/s10337-009-1225-6[Crossref]
• [18] Y. Choi, J.K. Kim, E. Ban, J.S. Park, C.K. Kim, J. Liq. Chromatogr. Rel. Technol. 31, 2643 (2008) http://dx.doi.org/10.1080/10826070802353189[Crossref]
• [19] R.M. Maggio, P.M. Castellano, T.S. Kaufman, Anal. Bioanal. Chem. 391, 2949 (2008) http://dx.doi.org/10.1007/s00216-008-2180-z[Crossref]
• [20] M.M. Baing, V.V. Vaidya, R.T. Sane, S.N. Menon, K. Dalvi, Chromatographia 64, 293 (2006) http://dx.doi.org/10.1365/s10337-006-0008-6[Crossref]
• [21] D.D. Rao, N.V. Satyanarayana, S.S. Sait, Y.R. Reddy, K. Mukkanti, Chromatographia 70, 647 (2009) http://dx.doi.org/10.1365/s10337-009-1221-x[Crossref]
• [22] C.F. Pedroso, J.G. de Oliveira, F.R. Campos, A.G. Gonçalves, A.C.L.B. Trindade, R. Pontarolo, Chromatographia 69, S201 (2009) http://dx.doi.org/10.1365/s10337-009-1005-3[Crossref]
• [23] M.R. Balesteros, A.F. Faria, M.A.L. de Oliveira, J. Braz. Chem. Soc. 18, 554 (2007) http://dx.doi.org/10.1590/S0103-50532007000300009[Crossref]
• [24] S. Hillaert, T.R.M. de Beer, J.O. de Beer, W. J. Van den Bossche, J. Chromatogr. A 984, 135 (2003) http://dx.doi.org/10.1016/S0021-9673(02)01832-0[Crossref]
• [25] L. Kristoffersen, E.L. Oiestad, M.S. Opdal, M. Krogh, E. Lundanes, A.O.S. Christophersen, J. Chromatogr. B 850, 147 (2007) http://dx.doi.org/10.1016/j.jchromb.2006.11.030[Crossref]
• [26] N. J. Erk, J. Pharm. Biomed. Anal. 24, 603 (2001) http://dx.doi.org/10.1016/S0731-7085(00)00434-9[Crossref]
• [27] D.L. Hertzog, J.F. McCafferty, X.G. Fang, R.J. Tyrell, R.A. Reed, J. Pharm. Biomed. Anal. 30, 747 (2002) http://dx.doi.org/10.1016/S0731-7085(02)00385-0[Crossref]
• [28] M.G. Quaglia, E. Donati, G. Carlucci, P. Mazzeo, S. Fanali, J. Pharm. Biomed. Anal. 29, 981 (2002) http://dx.doi.org/10.1016/S0731-7085(02)00138-3[Crossref]
• [29] E.C. Demiralay, B. Cubuk, S.A. Ozkan. G. Alsancak, J. Pharm. Biomed. Anal. 53, 475 (2010) http://dx.doi.org/10.1016/j.jpba.2010.05.020[Crossref]
• [30] E.R. Sartori, W.T. Suarez, O. Fatibello-Filho, Quim. Nova 32, 1947 (2009) http://dx.doi.org/10.1590/S0100-40422009000700043[Crossref]
• [31] B.C. Janegitz, W.T. Suarez, O. Fatibello-Filho, L.H. Marcolino-Junior, Anal. Lett. 41, 3264 (2008) http://dx.doi.org/10.1080/00032710802507554[Crossref]
• [32] F.R. Caetano, A. Gevaerd, M.F. Bergamini, L.H. Marcolino-Junior, Curr. Pharm. Anal. 7, 275 (2011) [Crossref]
• [33] Farmacopéia Brasileira (Atheneu, São Paulo, 1988)
• [34] British Pharmacopoeia (The Stationery Office, London, 2009)
• [35] European Pharmacopoeia (Council of Europe, Strasbourg, 2007)
• [36] J.N. Miller, J.C. Miller, Statistics for Analytical Chemistry (Prentice Hall, Dorchester, 2000)

Identifiers

DOI

10.2478/s11532-012-0110-6