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Journal
2012 | 10 | 1 | 216-223
Article title

Determination of lipophilicity for antitumor acridinone derivatives supported by gradient high-performance liquid chromatography method

Content
Title variants
Languages of publication
EN
Abstracts
EN
The lipophilicity values of selected acridinone (imidazoacridinone and triazoloacridinone) derivatives were measured by gradient reversed-phase high-performance liquid chromatography (RP-HPLC) using a C18 stationary phase with a water/acetonitrile mixture as a mobile phase. The retention times obtained served as input data and appropriate log kw values (i.e., the retention factor log kw extrapolated to 0% organic modifier) as an alternative to log P were calculated using the DryLab program. The relationships between the lipophilicity (log kw) and the chemical structure of the studied compounds, as well as correlation between experimentally determined lipophilicities (log kw) and log P data calculated using some commonly available software, are discussed.
Publisher

Journal
Year
Volume
10
Issue
1
Pages
216-223
Physical description
Dates
published
1 - 2 - 2012
online
24 - 11 - 2011
Contributors
author
  • Collegium Medicum of Nicolaus Copernicus University
author
  • Medical University of Gdańsk
  • Norwegian University of Science and Technology
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-011-0131-6
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