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Number of results

Journal

2012 | 10 | 1 | 216-223

Article title

Determination of lipophilicity for antitumor acridinone derivatives supported by gradient high-performance liquid chromatography method

Content

Title variants

Languages of publication

EN

Abstracts

EN
The lipophilicity values of selected acridinone (imidazoacridinone and triazoloacridinone) derivatives were measured by gradient reversed-phase high-performance liquid chromatography (RP-HPLC) using a C18 stationary phase with a water/acetonitrile mixture as a mobile phase. The retention times obtained served as input data and appropriate log kw values (i.e., the retention factor log kw extrapolated to 0% organic modifier) as an alternative to log P were calculated using the DryLab program. The relationships between the lipophilicity (log kw) and the chemical structure of the studied compounds, as well as correlation between experimentally determined lipophilicities (log kw) and log P data calculated using some commonly available software, are discussed.

Publisher

Journal

Year

Volume

10

Issue

1

Pages

216-223

Physical description

Dates

published
1 - 2 - 2012
online
24 - 11 - 2011

Contributors

author
  • Collegium Medicum of Nicolaus Copernicus University
author
  • Medical University of Gdańsk
  • Norwegian University of Science and Technology

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11532-011-0131-6
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