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Journal
2010 | 8 | 4 | 744-749
Article title

The protection of Nifedipin from photodegradation due to complex formation with β-cyclodextrin

Content
Title variants
Languages of publication
EN
Abstracts
EN
The inclusion complex β-cyclodextrin:nifedipin was prepared in solid state by coprecipitation with 1:1 mol ratio. The structure of the obtained complex and nifedipin was characterized by use of X-ray diffraction (XR), infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and differential scanning calorimetry (DSC) methods. The photodegradation of nifedipin and the β-cyclodextrin:nifedipin inclusion complex in solid state was monitored under natural daylight by infrared spectroscopy, whereby the free nifedipin degraded four to five times faster than the complexed nifedipin. The photodegradation products of both free and complexed nifedipin, formed during irradiation at 350 nm (with corresponding energy flux of 18 W m−2) were monitored by liquid chromatography during various time intervals. The speed of formation of nitroso- and nitro-phenyl derivatives by nifedipin irradiation was significantly higher than those of complexed nifedipin irradiation, which indicates its increased photostability in the inclusion complex. The effect on this property is significant because it contributes both to the improvement of the therapeutic effect of nifedipin and to the safer application thereof. [...]
Publisher

Journal
Year
Volume
8
Issue
4
Pages
744-749
Physical description
Dates
published
1 - 8 - 2010
online
17 - 6 - 2010
Contributors
  • Faculty of Technology, University of Nish, 16000, Leskovac, Serbia, nvesna@yahoo.com
author
  • Faculty of Technology, University of Nish, 16000, Leskovac, Serbia
  • Faculty of Technology, University of Nish, 16000, Leskovac, Serbia
  • Faculty of Technology, University of Nish, 16000, Leskovac, Serbia
  • Faculty of Technology, University of Nish, 16000, Leskovac, Serbia
  • Faculty of Technology, University of Nish, 16000, Leskovac, Serbia
author
  • Faculty of Sciences, Department of Physics, University of Novi Sad, 21000, Novi Sad, Serbia
  • Faculty of Sciences, Department of Chemistry, University of Novi Sad, 21000, Novi Sad, Serbia
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-010-0043-x
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