The protection of Nifedipin from photodegradation due to complex formation with β-cyclodextrin

• Authors: Vesna Nikolić , Dušica Ilić , Ljubiša Nikolić , Mihajlo Stanković , Milorad Cakić , Ljiljana Stanojević , Agneš Kapor , Mirjana Popsavin
• Languages of publication: EN

Abstracts

EN

The inclusion complex β-cyclodextrin:nifedipin was prepared in solid state by coprecipitation with 1:1 mol ratio. The structure of the obtained complex and nifedipin was characterized by use of X-ray diffraction (XR), infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and differential scanning calorimetry (DSC) methods. The photodegradation of nifedipin and the β-cyclodextrin:nifedipin inclusion complex in solid state was monitored under natural daylight by infrared spectroscopy, whereby the free nifedipin degraded four to five times faster than the complexed nifedipin. The photodegradation products of both free and complexed nifedipin, formed during irradiation at 350 nm (with corresponding energy flux of 18 W m−2) were monitored by liquid chromatography during various time intervals. The speed of formation of nitroso- and nitro-phenyl derivatives by nifedipin irradiation was significantly higher than those of complexed nifedipin irradiation, which indicates its increased photostability in the inclusion complex. The effect on this property is significant because it contributes both to the improvement of the therapeutic effect of nifedipin and to the safer application thereof. [...]

Keywords

EN

Nifedipin; Inclusion complex; β-cyclodextrin; Photodegradation; Liquid chromatography

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2010
• Volume: 8
• Issue: 4
• Pages: 744-749

Dates

published

1 - 8 - 2010

online

17 - 6 - 2010

Contributors

author

Vesna Nikolić

• Faculty of Technology, University of Nish, 16000, Leskovac, Serbia

author

Dušica Ilić

• Faculty of Technology, University of Nish, 16000, Leskovac, Serbia

author

Ljubiša Nikolić

• Faculty of Technology, University of Nish, 16000, Leskovac, Serbia

author

Mihajlo Stanković

• Faculty of Technology, University of Nish, 16000, Leskovac, Serbia

author

Milorad Cakić

• Faculty of Technology, University of Nish, 16000, Leskovac, Serbia

author

Ljiljana Stanojević

• Faculty of Technology, University of Nish, 16000, Leskovac, Serbia

author

Agneš Kapor

• Faculty of Sciences, Department of Physics, University of Novi Sad, 21000, Novi Sad, Serbia

author

Mirjana Popsavin

• Faculty of Sciences, Department of Chemistry, University of Novi Sad, 21000, Novi Sad, Serbia

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Identifiers

DOI

10.2478/s11532-010-0043-x